{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:20:49Z","timestamp":1778538049693,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T00:00:00Z","timestamp":1353283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Barrett's oesophagus (\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      ) is a premalignant condition associated with oesophageal adenocarcinoma. Although speculation exists, it is currently unclear if\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      is associated with an increased risk of colonic tumours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To conduct a meta\u2010analysis of studies reporting the prevalence of colonic tumours in patients with\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      vs. controls and thus quantify the risk of colonic tumours associated with\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A search was conducted through Medline, PubMed, Embase, and Current Contents Connect to 7 October 2012. We calculated pooled odds ratios (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      ) and 95% confidence intervals (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) using a random\u2010effects model for the risk of all colonic tumours associated with\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      , as well as for the subgroups of colorectal cancer (\n                      <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>\n                      ) and benign adenomatous tumours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 11 studies, with 2580\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      cases, met our inclusion criteria.\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      was associated with an increased risk of any colonic tumours (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      : 1.96; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.56\u20132.46).\n                      <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>\n                      was associated with an increased risk of benign adenomatous tumours (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      : 1.69; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.20\u20132.39), as well as an increased risk of\n                      <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      : 1.90; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 1.35\u20132.67). No statistically significant heterogeneity was observed. Publication bias was not present.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Barrett's oesophagus was associated with an increased risk of both benign adenomatous colonic tumours and colorectal cancer. Barrett's oesophagus had a stronger association with colorectal cancer than with benign colonic tumours. Further prospective cohort studies are needed to confirm the relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12146","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T23:34:12Z","timestamp":1353368052000},"page":"401-410","source":"Crossref","is-referenced-by-count":12,"title":["Meta\u2010analysis: Barrett's oesophagus and the risk of colonic tumours"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Andrici","sequence":"first","affiliation":[{"name":"The Whiteley\u2010Martin Research Centre The Discipline of Surgery The University of Sydney Sydney Medical School Penrith NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tio","sequence":"additional","affiliation":[{"name":"The Whiteley\u2010Martin Research Centre The Discipline of Surgery The University of Sydney Sydney Medical School Penrith NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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