{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:45:27Z","timestamp":1793094327773,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pernicious anaemia (\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      ) has an increased risk for gastric cancer (\n                      <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                      ). It is not established whether\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      patients need to undergo endoscopic\/histological follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To provide a systematic overview of the literature on\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      and the development of\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      , to estimate the\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      incidence\u2010rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      According to\n                      <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                      , we identified studies on\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      patients reporting the incidence of\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      . Quality of studies was evaluated using the Newcastle\u2010Ottawa Quality Assessment Scale. Meta\u2010analysis on annual\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      incidence rates was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven studies met eligibility criteria. 7 studies were of high, 6 of medium, 10 of low and 4 of very low quality.\n                      <jats:styled-content style=\"fixed-case\">Gastric cancer<\/jats:styled-content>\n                      incidence\u2010rates ranged from 0% to 0.2% per person\u2010years in 7 American, from 0% to 0.5% in 2 Asiatic, from 0% to 1.2% in 11 Northern European studies and from 0% to 0.9% in 7 studies from other European countries. The incidence\u2010rates of\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      ranged from 0% to 1.2% per person\u2010years in studies which used gastroscopy, from 0.1% to 0.9% in those based on\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      nternational\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      lassification of\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      isease. Heterogeneity between studies was not statistically significant at the 5% level (Chi\u2010squared test\u00a0=\u00a017.9,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.08). The calculated pooled\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      incidence\u2010rate was 0.27% per person\u2010years. Meta\u2010analysis showed overall\n                      <jats:styled-content style=\"fixed-case\">gastric cancer<\/jats:styled-content>\n                      relative risk in\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      as 6.8 (95% CI: 2.6\u201318.1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review shows a pooled gastric cancer incidence\u2010rate in pernicious anaemia of 0.27% per person\u2010years and an estimated nearly sevenfold relative risk of gastric cancer in pernicious anaemia patients. Further high quality studies are needed to confirm this higher risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12177","type":"journal-article","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T05:43:30Z","timestamp":1355118210000},"page":"375-382","source":"Crossref","is-referenced-by-count":210,"title":["Systematic review: gastric cancer incidence in pernicious anaemia"],"prefix":"10.1111","volume":"37","author":[{"given":"L.","family":"Vannella","sequence":"first","affiliation":[{"name":"Dipartimento Medico\u2010Chirurgico di Scienze Cliniche Tecnobiomediche e Medicina Traslazionale Sant'Andrea Hospital School of Medicine University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lahner","sequence":"additional","affiliation":[{"name":"Dipartimento Medico\u2010Chirurgico di Scienze Cliniche Tecnobiomediche e Medicina Traslazionale Sant'Andrea Hospital School of Medicine University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Dipartimento Sanit\u00e0 Pubblica e Malattie Infettive University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Annibale","sequence":"additional","affiliation":[{"name":"Dipartimento Medico\u2010Chirurgico di Scienze Cliniche Tecnobiomediche e Medicina Traslazionale Sant'Andrea Hospital School of Medicine University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"559","volume-title":"Clinical Haematology","author":"Wintrobe MM","year":"1981"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5121"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.475"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02074.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3534"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291491"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.228254"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_11_1","unstructured":"WellsGA SheaB;O'ConnellD et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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