{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:54:04Z","timestamp":1790776444812,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T00:00:00Z","timestamp":1355356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) on certain immunosuppressants have increased herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the risk of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> and how antitumour necrosis factor\u2010alpha (anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>) agents affect this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort and nested case\u2013control study using administrative data from IMS LifeLink<jats:sup>\u00ae<\/jats:sup> Information Assets\u2010Health Plan Claims Database. In the cohort, we identified <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients &lt;age 64 by diagnosis codes; matched to four individuals without <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> risk was evaluated by incidence rate ratio (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>) and adjusted Cox proportional hazards models (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>). In the nested case\u2013control analysis, 2659 <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> were each matched to four <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients without <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>. We determined associations between medications and <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> using conditional logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 50\u00a0932 patients with Crohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>), 56\u00a0403 patients with ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) and 1269 with unspecified <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>, matched to 434\u00a0416 individuals without <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> cohort had increased <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> risk compared with non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>: 1.68, 95% CI: 1.60\u20131.76). After adjustment, <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients had a higher risk of <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> than non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 1.49, 95% CI: 1.42\u20131.57). In the nested case\u2013control multivariate\u2010adjusted analyses, anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> medications (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.81, 95% CI: 1.48\u20132.21), corticosteroids (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.73, 95% CI: 1.51\u20131.99) and thiopurines (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.85, 95% CI: 1.61\u20132.13) were independently associated with HZ. Risk of HZ was highest with combination anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> and thiopurine therapy (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3.29, 95% CI: 2.33\u20134.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with inflammatory bowel disease are at increased risk for herpes zoster. Use of thiopurines, anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> agents, combination therapy and corticosteroids increases herpes zoster risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12182","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T22:59:59Z","timestamp":1355439599000},"page":"420-429","source":"Crossref","is-referenced-by-count":170,"title":["Increased risk of herpes zoster among 108\u00a0604 patients with inflammatory bowel disease"],"prefix":"10.1111","volume":"37","author":[{"given":"M. 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