{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:09:27Z","timestamp":1791320967080,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Enterocyte damage is the hallmark of coeliac disease (\n CD<\/jats:styled-content>\n ) resulting in malabsorption. Little is known about the recovery of enterocyte damage and its clinical consequences. Serum intestinal fatty acid binding protein (I\u2010\n FABP<\/jats:styled-content>\n ) is a sensitive marker to study enterocyte damage.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To evaluate the severity of enterocyte damage in adult\u2010onset\n CD<\/jats:styled-content>\n and its course upon a gluten\u2010free diet (\n GFD<\/jats:styled-content>\n ). Furthermore, the correlation among enterocyte damage,\n CD<\/jats:styled-content>\n autoantibodies and histological abnormalities during the course of disease is studied.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Serum I\u2010\n FABP<\/jats:styled-content>\n levels were determined in 96 biopsy\u2010proven adult\n CD<\/jats:styled-content>\n patients and in 69 patients repeatedly upon a\n GFD<\/jats:styled-content>\n . A total of 141 individuals with normal antitissue transglutaminase antibody (\n IgA<\/jats:styled-content>\n \u2010\n tTG<\/jats:styled-content>\n ) levels served as controls. I\u2010\n FABP<\/jats:styled-content>\n levels were related to the degree of villous atrophy (Marsh grade) and IgA\u2010\n tTG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n I\u2010\n FABP<\/jats:styled-content>\n levels were elevated in untreated\n CD<\/jats:styled-content>\n (median 691\u00a0pg\/mL) compared with controls (median 178\u00a0pg\/mL,\n P<\/jats:italic>\n \u00a0<\u00a00.001) and correlated with Marsh grade (\n r<\/jats:italic>\n \u00a0=\u00a00.265,\n P<\/jats:italic>\n \u00a0<\u00a00.05) and IgA\u2010\n tTG<\/jats:styled-content>\n (\n r<\/jats:italic>\n \u00a0=\u00a00.403,\n P<\/jats:italic>\n \u00a0<\u00a00.01). Upon a\n GFD<\/jats:styled-content>\n serum levels decreased significantly, however, not within the range observed in controls, despite the common observed normalisation of IgA\u2010\n tTG<\/jats:styled-content>\n levels and Marsh grade.\n CD<\/jats:styled-content>\n patients with elevated I\u2010\n FABP<\/jats:styled-content>\n levels nonresponding to\n GFD<\/jats:styled-content>\n showed persistent histological abnormalities.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Enterocyte damage assessed by serum I\u2010\n FABP<\/jats:styled-content>\n correlates with the severity of villous atrophy in\n coeliac disease<\/jats:styled-content>\n at the time of diagnosis. Although enterocyte damage improves upon treatment, substantial enterocyte damage persists despite absence of villous atrophy and low IgA\u2010\n tTG<\/jats:styled-content>\n levels in the majority of cases. Elevated I\u2010\n FABP<\/jats:styled-content>\n levels nonresponding to\n gluten\u2010free diet<\/jats:styled-content>\n are indicative of histological abnormalities and warrant further evaluation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12194","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T07:13:39Z","timestamp":1357542819000},"page":"482-490","source":"Crossref","is-referenced-by-count":191,"title":["Serum I\u2010\n FABP<\/scp>\n as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies"],"prefix":"10.1111","volume":"37","author":[{"given":"M. P. M.","family":"Adriaanse","sequence":"first","affiliation":[{"name":"Department of Paediatrics & Nutrition and Toxicology Research Institute Maastricht (NUTRIM) Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Small Bowel Unit Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Lima","family":"Passos","sequence":"additional","affiliation":[{"name":"Department of Methodology and Statistics Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G. M. C.","family":"Damoiseaux","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W. J.","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Department of Pathology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"van Wijck","sequence":"additional","affiliation":[{"name":"Department of General Surgery Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Riedl","sequence":"additional","affiliation":[{"name":"Department of Pathology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A. M.","family":"Masclee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"Buurman","sequence":"additional","affiliation":[{"name":"Department of General Surgery Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J. J.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Small Bowel Unit Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. 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