{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:12:22Z","timestamp":1790899942731,"version":"4.1.0"},"reference-count":173,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T00:00:00Z","timestamp":1358380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Home parenteral nutrition (<jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content>) is currently the management of choice for patients with chronic intestinal failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To summarise the major issues in delivering long\u2010term parenteral nutrition (&gt;3\u00a0months) and assess outcome as per complications, mortality and quality of life. To assess the evidence for the therapeutic use of trophic factors such as teduglutide and to review evolving therapeutic options in the treatment of chronic intestinal failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search using PubMed and <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> databases was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Safe delivery of <jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content> relies upon individualised formulations of parenteral nutrition administered via carefully maintained central venous catheters by trained patients or carers, supported by a skilled multidisciplinary team. Early diagnosis and treatment of complications including catheter\u2010associated blood stream infection (reported incidence 0.14\u20130.83 episodes\/patient\u2010year on <jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content>) and central venous thrombosis (reported incidence 0.03 episodes\/patient\u2010year) is important to minimise mortality and morbidity. There is a significant variation in the reported incidence of both hepatobiliary complications (19\u201375%) and advanced liver disease (0\u201350%). Five\u2010year survival rates in large centres are reported between 60% and 78% with survival primarily related to underlying diagnosis. Long\u2010term survival remains higher on <jats:styled-content style=\"fixed-case\">HPN<\/jats:styled-content> than with intestinal transplantation. The role of intestinal lengthening procedures is yet to be validated in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Home parenteral nutrition delivered by skilled nutrition teams has low incidences of catheter\u2010related complications. Most deaths relate to the underlying disease. Therapies such as teduglutide and small bowel transplantation appear promising, but home parenteral nutrition appears likely to remain the bedrock of management in the near term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12209","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T01:40:58Z","timestamp":1358473258000},"page":"587-603","source":"Crossref","is-referenced-by-count":139,"title":["Review article: the management of long\u2010term parenteral nutrition"],"prefix":"10.1111","volume":"37","author":[{"given":"M.","family":"Dibb","sequence":"first","affiliation":[{"name":"Intestinal Failure Unit Salford Royal Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Teubner","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit Salford Royal Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Theis","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit Salford Royal Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit Salford Royal Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lal","sequence":"additional","affiliation":[{"name":"Intestinal Failure Unit Salford Royal Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,17]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"672","article-title":"An evaluation of mixtures of ossein gelatin, hydrolyzed protein, a and glucose in the parenteral nutrition of postoperative patients","volume":"25","author":"Riegel C","year":"1949","journal-title":"Surgery"},{"key":"e_1_2_13_3_1","first-page":"699","article-title":"Parenteral nutrition; fat emulsions for intravenous nutrition in man","volume":"34","author":"Mann GV","year":"1949","journal-title":"J Lab Clin Med"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1936.02770060032009"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)33018-5"},{"key":"e_1_2_13_6_1","first-page":"219","volume-title":"Nutrition and the Surgical Patient","author":"Fleming CR","year":"1981"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02941.x"},{"key":"e_1_2_13_8_1","unstructured":"StewartJA MasonDG SmithN ProtopapaK MasonM.Parenteral Nutrition: A mixed bag. National Confidential Enquiry into Perioperative Deaths; 2010. Available at:http:\/\/www.ncepod.org.uk\/2010pn.htm. Accessed January 7 2013."},{"key":"e_1_2_13_9_1","unstructured":"SmithT HirstA JonesB BaxterJ.Annual BANS Report 2011. British Association of Parenteral and Enteral Nutrition; 2011. Available at:http:\/\/www.bapen.org.uk\/pdfs\/bans_reports\/bans_report_11.pdf. Accessed January 7 2013."},{"key":"e_1_2_13_10_1","unstructured":"SmithT HirstA JonesB BaxterJ.Annual BANS Report. British association of parenteral and enteral nutrition; 2009. Available at:http:\/\/www.bapen.org.uk\/pdfs\/bans_reports\/bans_report_10.pdf. Accessed January 7 2013."},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/j.1572-0241.2006.00710.x","article-title":"Candidates for intestinal transplantation: a multicenter survey in Europe","volume":"101","author":"Pironi L","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111434599"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0580"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311526"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20824"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010006650"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.04.001"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-7-200004040-00003"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1171"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000091683"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607198022005311"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/01486071040280S601"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(03)00173-4"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000165009.24202.64"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2000.0109"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860710402800285"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(98)00037-9"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199612000-00020"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7411.361"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcrc.2002.34364"},{"key":"e_1_2_13_31_1","unstructured":"NICE.TA49 Central venous catheters \u2013 ultrasound locating devices: guidance. 2002. Available at:http:\/\/guidance.nice.org.uk\/TA49\/Guidance\/pdf\/English. Accessed January 7 2013."},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90479-9"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000118101.94596.A0"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2003.11.015"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719902300285"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61865-X"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.005"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9902700206"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90305-Q"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.148.3.621"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.03.015"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031003234"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.01.001"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1980.03300450020013"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607100024006323"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.08.009"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70388-4"},{"key":"e_1_2_13_48_1","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1136\/gutjnl-2012-302514a.34","article-title":"OC\u2010034 Salvage of central venous catheters in HPN catheter\u2010related blood stream infections is safe and effective: 18\u00a0years experience from a national centre","volume":"61","author":"Dibb M","year":"2012","journal-title":"Gut"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03106.x"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2003.09.015"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000162286"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000212606.13348.f7"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800214"},{"key":"e_1_2_13_54_1","first-page":"138","article-title":"Reduction of complications associated with total parenteral nutrition by introduction of a clinical monitoring team. The Total Parenteral Nutrition Committee","volume":"11","author":"Oakes L","year":"1991","journal-title":"Aust Clin Rev"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010006642"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0578"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607197021006336"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.02.001"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607188012002185"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.12.005"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.04.013"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110362900"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(90)90023-L"},{"key":"e_1_2_13_64_1","doi-asserted-by":"crossref","first-page":"i","DOI":"10.3310\/hta1010","article-title":"Home parenteral nutrition: a systematic review","volume":"1","author":"Richards DM","year":"1997","journal-title":"Health Technol Assess"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)60693-8"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61575-9"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718000400410"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118195"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607195019005416"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607196020004302"},{"key":"e_1_2_13_71_1","article-title":"Catheter\u2010related complications in cancer patients on home parenteral nutrition a prospective study of over 51,000 catheter days","author":"Cotogni P","journal-title":"J Parenter Enteral Nutr"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.3.8430537"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.16.1913"},{"key":"e_1_2_13_74_1","first-page":"142","article-title":"Warfarin and reduced central venous thrombosis in home total parenteral nutrition patients","volume":"11","author":"Veerabagu MP","year":"1995","journal-title":"Nutrition"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-3-112-6-423"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90312-D"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(93)90022-V"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(99)80008-9"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.657"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2010.00756.x"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.11.1493"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(03)00108-2"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1999.98925"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00074-4"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.10.040"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0554"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1136\/fg.2009.000521"},{"key":"e_1_2_13_88_1","doi-asserted-by":"crossref","first-page":"S864","DOI":"10.1016\/S0016-5085(11)63589-0","article-title":"Aetiology, management of jaundice in adult patients with acute severe intestinal failure","volume":"140","author":"Kalaiselvan R","year":"2011","journal-title":"Gastroenterology"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400330060009"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.09.008"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607102026003198"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198520110-00011"},{"key":"e_1_2_13_93_1","first-page":"25","article-title":"Cholecystokinin prevents parenteral nutrition induced biliary sludge in humans","volume":"170","author":"Sitzmann JV","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_13_94_1","first-page":"G173","article-title":"Intravenous amino acids stimulate human gallbladder emptying and hormone release","volume":"259","author":"Nealon WH","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91146-D"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005340070022"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02518.x"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430170102020"},{"key":"e_1_2_13_99_1","first-page":"641","article-title":"Cholestasis caused by lipid emulsions","volume":"154","author":"Allardyce DB","year":"1982","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/35.6.1425"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002966510700585X"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607101025005260"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/44.3.398"},{"key":"e_1_2_13_104_1","unstructured":"National Institute of Clinical Excellence.Nutrition support in adults: oral nutrition support enteral tube feeding and parenteral nutrition.2006. Available at:http:\/\/guidance.nice.org.uk\/CG32\/Guidance\/pdf\/English. Accessed January 7 2013."},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.07.008"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283394879"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181de210c"},{"key":"e_1_2_13_108_1","first-page":"1347","article-title":"Early use of cyclic TPN prevents further deterioration of liver functions for the TPN patients with impaired liver function","volume":"47","author":"Hwang TL","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00472-X"},{"key":"e_1_2_13_110_1","first-page":"401","article-title":"Amino acid mixture designed to maintain normal plasma amino acid patterns in infants and children requiring parenteral nutrition","volume":"80","author":"Heird WC","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02972.x"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607105029005337"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061826"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-3-343"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-6-910"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607106030006492"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426507022003329"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0548"},{"key":"e_1_2_13_119_1","first-page":"88","article-title":"Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine","volume":"43","author":"Fitzgerald KA","year":"1986","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202317316006"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802200028"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607196020004275"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20227"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.08.010"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-003-1016-3"},{"key":"e_1_2_13_126_1","first-page":"63","article-title":"Intestinal morphology and transport after ileal resection in rat is modified by dietary fatty acids","volume":"19","author":"Keelan M","year":"1996","journal-title":"Clin Invest Med"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015165"},{"key":"e_1_2_13_128_1","first-page":"489","article-title":"No differences in mucosal adaptive growth one week after intestinal resection in rats given enteral glutamine supplementation or deprived of glutamine","volume":"162","author":"Wir\u00e9n ME","year":"1996","journal-title":"Eur J Surg"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90306-7"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50057"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(02)02654-4"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199509000-00003"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607104028006377"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000186479.53295.14"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199701000-00010"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322500"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.199"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.32273"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.3109\/08977199409010990"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.5.G700"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607100024005288"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607103027003198"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6153"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01723.x"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007"},{"key":"e_1_2_13_147_1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/gut.2004.061440","article-title":"Teduglutide (ALX\u20100600) a dipeptidyl peptidase IV resistant glucagon\u2010like peptide 2 analogue, improves intestinal function in short bowel syndrome patients","volume":"54","author":"Jeppesen PB","journal-title":"Gut"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22555"},{"key":"e_1_2_13_149_1","unstructured":"WalesPW NasrA DeSilva N YamadaJ.Human growth hormone and glutamine for patients with short bowel syndrome. Cochrane Database of Systematic Reviews. John Wiley & Sons Ltd; 1996. Available at:http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/14651858.CD006321.pub2\/abstract. Accessed January 7 2013."},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09519-3"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09561-2"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2006.05.003"},{"key":"e_1_2_13_153_1","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1136\/gutjnl-2012-302514a.32","article-title":"OC\u2010032 Outcome on home parenteral nutrition: 33\u00a0years experience from a national centre","volume":"61","author":"Dibb M","year":"2012","journal-title":"Gut"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1996.02308.x"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.12.008"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.6.844"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90196-5"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.4065\/74.3.217"},{"key":"e_1_2_13_159_1","doi-asserted-by":"crossref","unstructured":"AmiotA MessingB CorcosO PanisY JolyF.Determinants of home parenteral nutrition dependence and survival of 268 patients with non\u2010malignant short bowel syndrome. Available at:http:\/\/dx.doi.org\/10.1016\/j.clnu.2012.08.007. Accessed January 7 2013.","DOI":"10.1016\/j.clnu.2012.08.007"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031006508"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.223255"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9416-6"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)70064-X"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.005002080.x"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.237586"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.241075"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00218-4"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.070"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.07.029"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.12.033"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318155aa0c"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1291-y"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(80)80005-4"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50073"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:01:45Z","timestamp":1700672505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,17]]},"references-count":173,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/apt.12209"],"URL":"https:\/\/doi.org\/10.1111\/apt.12209","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,17]]}}}