{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:42:26Z","timestamp":1791805346722,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Higher body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) is a recognised risk factor for gastro\u2010oesophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>). Data regarding the impact of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> on proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) therapy are conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the impact of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> on baseline heartburn symptom severity and frequency and response to <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy in patients with non\u2010erosive <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>) or erosive oesophagitis (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In <jats:italic>post hoc<\/jats:italic> analyses of phase 3 trial data, 621 <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and 2692 <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> patients were stratified by <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (&lt;25, 25 to &lt;30 and \u226530\u00a0kg\/m<jats:sup>2<\/jats:sup>). <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> patients received either dexlansoprazole <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> 30\u00a0mg or placebo daily for 4\u00a0weeks. <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> patients received either dexlansoprazole <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> 60\u00a0mg or lansoprazole 30\u00a0mg for 8\u00a0weeks. Symptom frequency and severity were assessed at baseline and subsequently by daily diary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both the <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> cohorts, baseline heartburn severity increased with increasing <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. The impact of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy on the reduction in heartburn symptom frequency and severity in both <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> patients was similar across <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> categories. <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> healing rates in patients treated with dexlansoprazole but not lansoprazole were higher in obese patients compared with those with a <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &lt;30\u00a0kg\/m<jats:sup>2<\/jats:sup>. Differences between the <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s were small.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s evaluated in this study reduced the frequency and severity of 24\u2010h heartburn regardless of baseline <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. In addition, because patients with higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> have more severe symptoms at baseline, they may experience greater therapeutic gain with dexlansoprazole (<jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> and erosive oesophagitis) and possibly lansoprazole (erosive oesophagitis) treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12270","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T22:09:33Z","timestamp":1362434973000},"page":"810-818","source":"Crossref","is-referenced-by-count":17,"title":["The effects of increasing body mass index on heartburn severity, frequency and response to treatment with dexlansoprazole or lansoprazole"],"prefix":"10.1111","volume":"37","author":[{"given":"D. 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