{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:41Z","timestamp":1787013881956,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T00:00:00Z","timestamp":1362355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Studies have shown an increased risk of ischaemic heart disease (\n IHD<\/jats:styled-content>\n ) in patients with coeliac disease (\n CD<\/jats:styled-content>\n ), despite the patients' lack of traditional\n IHD<\/jats:styled-content>\n risk factors.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To characterise\n IHD<\/jats:styled-content>\n according to\n CD<\/jats:styled-content>\n status.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data on duodenal or jejunal biopsies were collected in 2006\u20132008 from all 28 pathology departments in Sweden and were used to define\n CD<\/jats:styled-content>\n (equal to villous atrophy; Marsh stage 3). We used the Swedish cardiac care register\n SWEDEHEART<\/jats:styled-content>\n to identify\n IHD<\/jats:styled-content>\n and to obtain data on clinical status and risk factors at time of first myocardial infarction for this case\u2010only comparison. Logistic regression was used to estimate odds ratios (\n OR<\/jats:styled-content>\n s) and 95% confidence intervals (\n CI<\/jats:styled-content>\n s).\n CD<\/jats:styled-content>\n patients were compared with general population reference individuals.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified 1075\n CD<\/jats:styled-content>\n patients and 4142 reference individuals with subsequent\n IHD<\/jats:styled-content>\n .\n CD<\/jats:styled-content>\n patients with myocardial infarction had lower body mass index (\n P<\/jats:italic>\n \u00a0<\u00a00.001) and cholesterol values (\n P<\/jats:italic>\n \u00a0<\u00a00.001) and were less likely to be active smokers (\n OR<\/jats:styled-content>\n \u00a0=\u00a00.74; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.56\u20130.98) than reference individuals with myocardial infarction.\n CD<\/jats:styled-content>\n patients had less extensive coronary artery disease at angiography (any stenosis:\n OR<\/jats:styled-content>\n \u00a0=\u00a00.80; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.66\u20130.97; three\u2010vessel disease:\n OR<\/jats:styled-content>\n \u00a0=\u00a00.73; 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.57\u20130.94); but there was no difference in the proportions of\n CD<\/jats:styled-content>\n patients with positive biochemical markers of myocardial infarction (\n CD<\/jats:styled-content>\n : 92.2% vs. reference individuals: 91.5%,\n P\u00a0<\/jats:italic>\n =\u00a00.766).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Despite evidence of an increased risk of\n IHD<\/jats:styled-content>\n and higher cardiovascular mortality, patients with coeliac disease with\n IHD<\/jats:styled-content>\n have a more favourable cardiac risk profile compared with\n IHD<\/jats:styled-content>\n in reference individuals.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12271","type":"journal-article","created":{"date-parts":[[2013,3,4]],"date-time":"2013-03-04T20:51:41Z","timestamp":1362430301000},"page":"905-914","source":"Crossref","is-referenced-by-count":50,"title":["The characterisation and risk factors of ischaemic heart disease in patients with coeliac disease"],"prefix":"10.1111","volume":"37","author":[{"given":"L.","family":"Emilsson","sequence":"first","affiliation":[{"name":"V\u00e5rdcentralen V\u00e4rmlands Nys\u00e4ter V\u00e4rmland County Sweden"},{"name":"Department of Medicine \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"PCI unit Department of Cardiology Central Hospital Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska University Hospital and Karolinska Institutet Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Cardiology and Uppsala Clinical Research Center Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska University Hospital and Karolinska Institutet Sweden"},{"name":"Department of Pediatrics \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1320"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03594.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.965624"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92843-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02008.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520903132013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.60"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04040.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00414-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-19"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9350-y"},{"key":"e_1_2_8_14_1","unstructured":"National Board of Health and Wellfare. 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