{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:18:07Z","timestamp":1775243887866,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T00:00:00Z","timestamp":1362528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the short\u2010term benefits of a sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) to interferon\u2010based therapies of chronic hepatitis C (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) are well known, the long\u2010term consequences of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> are less clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess changes in markers of disease activity and fibrosis in patients followed up to 23\u00a0years post\u2010<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The first 103 <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> patients (from 1984 to 2003) at the National Institutes of Health Clinical Center were evaluated. Serum markers before treatment and at the last visit were compared. Evaluations after 2007 included transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 103 patients, three subsequently relapsed 0.7, 6.3 and 6.5\u00a0years post therapy. The remaining 100 patients (56 men, mean age 56\u00a0years) maintained SVR at final follow\u2010up. No patients developed hepatic decompensation, but one with pre\u2010treatment cirrhosis died 12\u00a0years post SVR of hepatocellular carcinoma. In comparison to pre\u2010treatment values, markers improved at follow\u2010up, including mean ALT (152\u201327\u00a0U\/L), AST (87\u201324\u00a0U\/L), alkaline phosphatase (78\u201369\u00a0U\/L), IgG (1463\u20131113\u00a0mg\/dL), platelet count (209\u00a0000\u2013239\u00a0000\/\u03bcL) and AST to platelet count ratio index (APRI: 1.31\u20130.33). TE was performed in 69 patients and was normal (&lt;7.0\u00a0kPA) in 60%, moderately elevated (7.1\u201313.8) in 31% and cirrhotic range (&gt;13.8) in 9%. TE and platelet counts at follow\u2010up correlated with fibrosis on pre\u2010treatment liver biopsy (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In 97% of patients with <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SVR<\/jats:styled-content> is durable without evidence of disease progression, although some degree of hepatic fibrosis may persist and patients with pre\u2010treatment cirrhosis are at continuing low risk for hepatocellular carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12273","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T10:18:14Z","timestamp":1362565094000},"page":"887-894","source":"Crossref","is-referenced-by-count":42,"title":["Long\u2010term outcome of chronic hepatitis <scp>C<\/scp> after sustained virological response to interferon\u2010based therapy"],"prefix":"10.1111","volume":"37","author":[{"given":"C.","family":"Koh","sequence":"first","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Heller","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Haynes\u2010Williams","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hara","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Feld","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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G.","family":"Ghany","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch Division of Intramural Research National Institute of Diabetes and Digestive and Kidney Diseases and the Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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