{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:40:01Z","timestamp":1772160001155,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Serological markers such as anti\u2010neutrophil cytoplasmic antibody (\n ANCA<\/jats:styled-content>\n ) and anti\u2010\n \n S<\/jats:styled-content>\n accharomyces cerevisiae\n <\/jats:italic>\n antibody (\n ASCA<\/jats:styled-content>\n ) may be associated with pouchitis after ileal pouch\u2010anal anastomosis (\n IPAA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To perform a systematic review with meta\u2010analysis of studies evaluating the association of\n ANCA<\/jats:styled-content>\n and\n ASCA<\/jats:styled-content>\n status with risk of acute and chronic pouchitis after\n IPAA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We searched multiple databases (upto\n S<\/jats:styled-content>\n eptember 2012) for studies reporting\n ANCA<\/jats:styled-content>\n and\/or\n ASCA<\/jats:styled-content>\n status along with risk of acute or chronic pouchitis after\n IPAA<\/jats:styled-content>\n in adults with ulcerative colitis (\n UC<\/jats:styled-content>\n ). We abstracted odds ratio (\n OR<\/jats:styled-content>\n ) or raw data from the individual studies to calculate summary\n OR<\/jats:styled-content>\n estimates with 95%\n CI<\/jats:styled-content>\n s using random\u2010effects model.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eight studies reporting 184 cases of acute pouchitis and six studies reporting 151 cases of chronic pouchitis were included. The odds of chronic pouchitis were 76% higher in\n ANCA<\/jats:styled-content>\n \u2010positive patients than\n ANCA<\/jats:styled-content>\n \u2010negative (six studies;\n OR<\/jats:styled-content>\n : 1.76; 95%\n CI<\/jats:styled-content>\n : 1.19\u20132.61;\n P<\/jats:italic>\n \u00a0<\u00a00.01). ASCA\u2010positivity was not associated with the risk of chronic pouchitis (three studies;\n OR<\/jats:styled-content>\n : 0.89; 95%\n CI<\/jats:styled-content>\n : 0.49\u20131.59;\n P<\/jats:italic>\n \u00a0=\u00a00.68). Neither\n ANCA<\/jats:styled-content>\n (eight studies;\n OR<\/jats:styled-content>\n : 1.54; 95%\n CI<\/jats:styled-content>\n : 0.79\u20133.02;\n P<\/jats:italic>\n \u00a0=\u00a00.21) nor\n ASCA<\/jats:styled-content>\n \u2010positivity (two studies;\n OR<\/jats:styled-content>\n : 1.28; 95%\n CI<\/jats:styled-content>\n : 0.25\u20136.54;\n P<\/jats:italic>\n \u00a0=\u00a00.77) were associated with the risk of acute pouchitis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The risk of chronic pouchitis after\n IPAA<\/jats:styled-content>\n is higher in\n ANCA<\/jats:styled-content>\n \u2010positive patients, but the risk of acute pouchitis is unaffected by\n ANCA<\/jats:styled-content>\n status.\n ASCA<\/jats:styled-content>\n status was not associated with the risk of acute or chronic pouchitis. This information may be used to counsel\n UC<\/jats:styled-content>\n patients regarding their risk of pouchitis after\n IPAA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12274","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T21:15:52Z","timestamp":1363122952000},"page":"867-875","source":"Crossref","is-referenced-by-count":47,"title":["Meta\u2010analysis: serological markers and the risk of acute and chronic pouchitis"],"prefix":"10.1111","volume":"37","author":[{"given":"S.","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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