{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:04:19Z","timestamp":1765667059382},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent advances in eosinophilic oesophagitis (EoE) have confirmed the existence of a new disease phenotype, proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>)\u2010responsive oesophageal eosinophilia (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To summarise evidence supporting the use of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy in patients with suspected EoE (oesophageal dysfunction plus &gt;15 eos\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content> in oesophageal biopsies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was conducted through <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, using the Me<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content> search terms \u2018eosinophilic oesophagitis\u2019, \u2018proton pump inhibitors\u2019 and \u2018oesophageal eosinophilia\u2019. Relevant articles and their reference lists were identified through manual review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten articles, including 258 patients with suspected EoE (152 children, 106 adults) undergoing clinico\u2010histological re\u2010evaluation after PPI therapy, were identified. In children, clinical response ranged from 78% to 86% and histological remission from 23% to 40%. In adults, symptom response ranged from 25% to 80% and histological remission from 33% to 61%. Among PPI\u2010REE patients with oesophageal <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010monitoring, 35 showed pathological and 10 normal studies. PPI\u2010REE was significantly commoner with documented gastro\u2010oesophageal reflux disease (GERD) when compared to patients with negative <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring (70% vs. 29%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Symptom improvement\/resolution occurred in 50\u201385% of patients without histological remission on PPI therapy. Six PPI\u2010REE patients demonstrated clinico\u2010histological relapse on PPI therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At least one third of patients with suspected EoE achieve clinico\u2010histological remission on PPI therapy. Response is more limited in children compared with that in adults. <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring does not accurately predict response to PPI therapy, albeit histological remission is significantly higher, up to 70%, upon documented GERD. Symptom improvement is common with PPI therapy despite persistent eosinophilic infiltration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12332","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T03:54:12Z","timestamp":1368071652000},"page":"1157-1164","source":"Crossref","is-referenced-by-count":64,"title":["Review article: proton pump inhibitor therapy for suspected eosinophilic oesophagitis"],"prefix":"10.1111","volume":"37","author":[{"given":"J.","family":"Molina\u2010Infante","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Katzka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de la Princesa Instituto de Investigaci\u00f3n Sanitaria Princesa (IP) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01179.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00562.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.042"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819c4b3e"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0859-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0295-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04922.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.8670"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.02.024"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.443"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182716b7a"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1991-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02713-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00313-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01340.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03682.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2010.01051.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.06.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04476.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181eb5a9f"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800871"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04018.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40978.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.055"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0951-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.023"},{"key":"e_1_2_7_32_1","first-page":"e50037","article-title":"Omeprazole blocks eotaxin\u20103 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD","volume":"7","author":"Cheng E","year":"2012","journal-title":"Gut"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050037"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.459"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903469931"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.048"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.01.017"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:03:16Z","timestamp":1697598196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,8]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/apt.12332"],"URL":"https:\/\/doi.org\/10.1111\/apt.12332","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,8]]}}}