{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:37:22Z","timestamp":1789025842073,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Scant information is available regarding patients with upper gastrointestinal bleeding (\n UGIB<\/jats:styled-content>\n ) from tumours.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To determine the presentation, endoscopic findings, treatment and outcomes in patients with\n UGIB<\/jats:styled-content>\n from malignant tumours and identify risk factors associated with rebleeding.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Consecutive patients who were hospitalised with haematemesis, melena or haematochezia and underwent upper endoscopy were identified retrospectively by reviewing an endoscopy database. Patients with\n UGIB<\/jats:styled-content>\n due to biopsy\u2010proven malignant tumours were studied.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Tumours were the source of bleeding in 106 (5%) of 2,166 patients with\n UGIB<\/jats:styled-content>\n . Tumours were oesophageal in 17 (16%), gastric in 77 (73%) and duodenal in 12 (11%). At presentation, 84 (79%) did not have known cancer previously, and 79 (75%) had metastatic disease. Seventy\u2010seven (73%) received transfusions at index hospitalisation. At endoscopy, 32 (30%) had active bleeding (31 oozing, 1 spurting). Among actively bleeding patients, haemostasis was achieved in 12 (86%) of 14 receiving endoscopic therapy and all 18 not receiving endoscopic treatment. Hospitalisation for rebleeding occurred in 50 (49%) of 103 at a median of 30\u00a0days (3\u2013885). On multivariate analysis, age \u226460\u00a0years (OR\u00a0=\u00a02.49, 95% CI 1.06\u20135.81) and haemodynamic instability (OR\u00a0=\u00a02.42, 95% CI 1.08\u20135.46) were associated with rebleeding.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients presenting with tumour\u2010associated\n UGIB<\/jats:styled-content>\n have substantial blood loss, with three\u2010quarters requiring transfusion at presentation. Initial haemostasis occurs in almost all patients, with or without endoscopic therapy, but rebleeding requiring repeat hospitalisation occurs in approximately half the patients and is more common in patients who are \u226460\u00a0years of age and have haemodynamic instability at presentation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12347","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T05:10:50Z","timestamp":1369717850000},"page":"144-150","source":"Crossref","is-referenced-by-count":106,"title":["Natural history of acute upper\n GI<\/scp>\n bleeding due to tumours: short\u2010term success and long\u2010term recurrence with or without endoscopic therapy"],"prefix":"10.1111","volume":"38","author":[{"given":"S.","family":"Sheibani","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Loma Linda University Medical Center Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Saberi","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Keyashian","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Buxbaum","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Laine","sequence":"additional","affiliation":[{"name":"Section of Digestives Diseases Yale University School of Medicine CT and VA Connecticut Healthcare System New Haven West Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.168"},{"key":"e_1_2_7_3_1","first-page":"274","article-title":"Upper gastrointestinal tract hemorrhage","volume":"155","author":"Laine L","year":"1991","journal-title":"West J Med"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61090-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1005436"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770106"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7425.1192"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.702"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004640000266"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/1092642041255522"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.04.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(95)70342-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930450314"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2009.77"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0467-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0127-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.213"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.987"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001101)89:9<1883::AID-CNCR3>3.3.CO;2-8"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:55:00Z","timestamp":1696330500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/apt.12347"],"URL":"https:\/\/doi.org\/10.1111\/apt.12347","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}