{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:21:17Z","timestamp":1770484877847,"version":"3.49.0"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dexlansoprazole is a new proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) with a dual delayed\u2010release system. Both dexlansoprazole and esomeprazole are an enantiomer of lansoprazole and omeprazole respectively. However, there is no head\u2010to\u2010head trial data or indirect comparison analyses between dexlansoprazole and esomeprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the efficacy of dexlansoprazole with esomeprazole in healing erosive oesophagitis (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>), the maintenance of healed <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> and the treatment of non\u2010erosive reflux disease (<jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomised Controlled Trials (RCTs) comparing dexlansoprazole or esomeprazole with either placebo or another <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> were systematically reviewed. Random\u2010effect meta\u2010analyses and adjusted indirect comparisons were conducted to compare the treatment effect of dexlansoprazole and esomeprazole using a common comparator. The relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The indirect comparisons revealed significant differences in symptom control of heartburn in patients with <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> at 4\u00a0weeks. Dexlansoprazole 30\u00a0mg was more effective than esomeprazole 20\u00a0mg or 40\u00a0mg (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>: 2.01, 95% CI: 1.15\u20133.51; <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>: 2.17, 95% CI: 1.39\u20133.38). However, there were no statistically significant differences between the two drugs in <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> healing and maintenance of healed <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>. Comparison of symptom control in healed <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> was not able to be made due to different definitions used in the <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjusted indirect comparisons based on currently available <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> data suggested significantly better treatment effect in symptom control of heartburn in patients with <jats:styled-content style=\"fixed-case\">NERD<\/jats:styled-content> for dexlansoprazole against esomeprazole. No statistically significant differences were found in other <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> outcomes. However, these study findings need to be interpreted with caution due to small number of studies and other limitations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12349","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T01:37:42Z","timestamp":1369877862000},"page":"190-201","source":"Crossref","is-referenced-by-count":18,"title":["Indirect comparison of randomised controlled trials: comparative efficacy of dexlansoprazole vs. esomeprazole in the treatment of gastro\u2010oesophageal reflux disease"],"prefix":"10.1111","volume":"38","author":[{"given":"M. S.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Taiwan National University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Tan","sequence":"additional","affiliation":[{"name":"Double Helix Consulting Asia Pacific Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41217.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03901.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/296584"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02605.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.05.027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02531.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02339.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03443.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310002157"},{"key":"e_1_2_8_13_1","unstructured":"Takeda Pharmaceutical Company Limited.FDA Approves KAPIDEX\u2122(dexlansoprazole) delayed release capsules for the Treatment of GERD \u2010 First proton pump inhibitor (PPI) with a Dual Delayed Release\u2122(DDR) formulation.2009. Available at:http:\/\/www.takeda.com\/news\/2009\/20090131_3671.html. Accessed February 2013."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.08.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S24063"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_8_18_1","volume-title":"Systematic Reviews. CRD's Guidance for Undertaking Reviews in Health Care","author":"Centre for Reviews and Dissemination","year":"2009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.06.022"},{"key":"e_1_2_8_20_1","unstructured":"HigginsJPT GreenSE.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]: The Cochrane Collaboration. Available at:www.cochrane-handbook.org. Accessed February 2013."},{"key":"e_1_2_8_21_1","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_8_22_1","unstructured":"Review Manager (RevMan) [Computer program]. Version 5.2.Copenhagen:The Nordic Cochrane Centre The Cochrane Collaboration.2012."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(97)00049-8"},{"key":"e_1_2_8_24_1","volume-title":"Indirect Evidence: Indirect Treatment Comparisons in Meta\u2010Analysis","author":"Wells GA","year":"2009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7387.472"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05532.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04013.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.458"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04119.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04339.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00285.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01771.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03954.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03933.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00943.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200208000-00008"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0402-1"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01024.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.990"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02233.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80087-4"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04315.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00288-5"},{"issue":"2","key":"e_1_2_8_45_1","first-page":"CD003245","article-title":"Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease","author":"Donnellan C","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01128.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04077.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.013"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05879.x"},{"key":"e_1_2_8_50_1","first-page":"653","article-title":"A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD)","volume":"3","author":"Kalaitzakis E","year":"2007","journal-title":"Ther Clin Risk Manag"},{"issue":"2","key":"e_1_2_8_51_1","first-page":"CD003244","article-title":"WITHDRAWN: medical treatments in the short term management of reflux oesophagitis","author":"Moayyedi P","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03381.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)80207-2"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812436933"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00904.x"},{"issue":"11","key":"e_1_2_8_56_1","first-page":"CD002095","article-title":"Short\u2010term treatment with proton pump inhibitors, H2\u2010receptor antagonists and prokinetics for gastro\u2010oesophageal reflux disease\u2010like symptoms and endoscopy negative reflux disease","author":"van Pinxteren B","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01888.x"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200222020-00004"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02072.x"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.06.006"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4909"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060684"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.11.021"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04774.x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039471"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70544-5"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:55:36Z","timestamp":1696344936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,29]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/apt.12349"],"URL":"https:\/\/doi.org\/10.1111\/apt.12349","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,29]]}}}