{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:40Z","timestamp":1787013880890,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accelerated progression of atherosclerosis and increased cardiovascular risk have been described in immune\u2010mediated disorders, but few data are available in coeliac disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate instrumental and biochemical signs of atherosclerosis risk in 20 adults at first diagnosis of coeliac disease and after 6\u20138\u00a0months of gluten\u2010free diet with mucosal recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed total, high\u2010density lipoprotein (\n                      <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                      ) and low\u2010density lipoprotein (\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      ) cholesterol, triglycerides, homocysteine, C\u2010reactive protein, folate and vitamin B12; ultrasound measurement of carotid intima\u2010media thickness (IMT) and endothelium\u2010dependent dilatation were both carried on at diagnosis and after gluten withdrawal. Twenty\u2010two healthy members of the hospital staff served as matched controls for vascular examinations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, mean total and\n                      <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                      \u2010cholesterol (HDL\u2010C) were both within normal range, while mean\n                      <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                      \u2010cholesterol concentration was slightly increased; diet was associated with an increment in total and\n                      <jats:styled-content style=\"fixed-case\">HDL\u2010C<\/jats:styled-content>\n                      (68.2\u00a0\u00b1\u00a017.4 vs. 51.4\u00a0\u00b1\u00a018.6\u00a0mg\/dL;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and a significant improvement in total\/\n                      <jats:styled-content style=\"fixed-case\">HDL\u2010C<\/jats:styled-content>\n                      ratio (3.05\u00a0\u00b1\u00a00.71 vs. 3.77\u00a0\u00b1\u00a00.92;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.02). Mean plasma homocysteine was elevated and not influenced by diet. C\u2010reactive protein significantly decreased with diet (1.073\u00a0\u00b1\u00a00.51 vs. 1.92\u00a0\u00b1\u00a01.38\u00a0mg\/dL;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). At baseline, in coeliacs, IMT was increased (0.082\u00a0\u00b1\u00a00.011 vs. 0.058\u00a0\u00b1\u00a00.012\u00a0cm;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.005), while endothelium\u2010dependent dilatation was decreased (9.3\u00a0\u00b1\u00a01.3 vs. 11.2\u00a0\u00b1\u00a01.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Both parameters improved after gluten abstinence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adults with coeliac disease seem to be at potentially increased risk of early atherosclerosis as suggested by vascular impairment and unfavourable biochemical risk pattern. Chronic inflammation might play a determining role. Gluten abstinence with mucosal normalisation reverts to normal the observed alterations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12360","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T23:49:36Z","timestamp":1370303376000},"page":"162-169","source":"Crossref","is-referenced-by-count":73,"title":["Young adults with coeliac disease may be at increased risk of early atherosclerosis"],"prefix":"10.1111","volume":"38","author":[{"given":"S.","family":"De Marchi","sequence":"first","affiliation":[{"name":"Division of Vascular Rehabilitation Department of Medicine University of Verona Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chiarioni","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona Verona Italy"},{"name":"Division of Gastroenterology and Hepatology Center for Functional GI and Motility Disorders University of North Carolina Chapel Hill NC 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