{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:58:23Z","timestamp":1765807103031},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":803,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1111\/apt.12378","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T03:37:44Z","timestamp":1371785864000},"page":"313-323","source":"Crossref","is-referenced-by-count":19,"title":["Genetic variation in the beta-2 adrenergic receptor (ADRB2) predicts functional gastrointestinal diagnoses and poorer health-related quality of life"],"prefix":"10.1111","volume":"38","author":[{"given":"V. M.","family":"Kushnir","sequence":"first","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cassell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Newberry","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kibe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. D.","family":"Nix","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sabzpoushan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. D.","family":"Kanuri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology; Washington University School of Medicine; St. Louis; MO; USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Sayuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"10.1111\/apt.12378-BIB0001|apt12378-cit-0001","first-page":"487","volume-title":"Rome III: The Functional Gastrointestinal Disorders","author":"Longstreth","year":"2006"},{"key":"10.1111\/apt.12378-BIB0002|apt12378-cit-0002","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1056\/NEJMcp0801447","article-title":"Clinical practice. Irritable bowel syndrome","volume":"358","author":"Mayer","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1111\/apt.12378-BIB0003|apt12378-cit-0003","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nrgastro.2010.4","article-title":"Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions","volume":"7","author":"Ohman","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1111\/apt.12378-BIB0004|apt12378-cit-0004","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1053\/j.gastro.2011.01.032","article-title":"The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome","volume":"140","author":"Chang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.12378-BIB0005|apt12378-cit-0005","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1053\/j.gastro.2010.02.037","article-title":"Genetic approaches to functional gastrointestinal disorders","volume":"138","author":"Saito","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.12378-BIB0006|apt12378-cit-0006","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1023\/A:1016424007454","article-title":"Evidence for autonomic dysregulation in the irritable bowel syndrome","volume":"47","author":"Gupta","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1111\/apt.12378-BIB0007|apt12378-cit-0007","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/gast.2002.32392","article-title":"Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?","volume":"122","author":"Whitehead","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.12378-BIB0008|apt12378-cit-0008","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"J Psychosom Res"},{"key":"10.1111\/apt.12378-BIB0009|apt12378-cit-0009","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar2146","article-title":"Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia","volume":"9","author":"Martinez-Lavin","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/apt.12378-BIB0010|apt12378-cit-0010","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1185\/03007995.2011.614934","article-title":"Mechanisms of pain transmission and pharmacologic management","volume":"27","author":"Argoff","year":"2011","journal-title":"Curr Med Res Opin"},{"key":"10.1111\/apt.12378-BIB0011|apt12378-cit-0011","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/FPC.0b013e328337f9ab","article-title":"Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study","volume":"20","author":"Tchivileva","year":"2010","journal-title":"Pharmacogenet Genomics"},{"key":"10.1111\/apt.12378-BIB0012|apt12378-cit-0012","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pain.2006.09.022","article-title":"Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors","volume":"128","author":"Nackley","year":"2007","journal-title":"Pain"},{"key":"10.1111\/apt.12378-BIB0013|apt12378-cit-0013","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ajmg.b.30324","article-title":"Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder","volume":"141B","author":"Diatchenko","year":"2006","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1111\/apt.12378-BIB0014|apt12378-cit-0014","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pain.2010.01.023","article-title":"Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study","volume":"149","author":"Hocking","year":"2010","journal-title":"Pain"},{"key":"10.1111\/apt.12378-BIB0015|apt12378-cit-0015","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1002\/art.24655","article-title":"Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains","volume":"60","author":"Vargas-Alarcon","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1111\/apt.12378-BIB0016|apt12378-cit-0016","volume-title":"Rome III: the Functional Gastrointestinal Disorders","author":"Drossman","year":"2006"},{"key":"10.1111\/apt.12378-BIB0017|apt12378-cit-0017","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s00464-002-8538-y","article-title":"Influence of spastic motor disorders of the esophageal body on outcomes from laparoscopic antireflux surgery","volume":"17","author":"Winslow","year":"2003","journal-title":"Surg Endosc"},{"key":"10.1111\/apt.12378-BIB0018|apt12378-cit-0018","volume-title":"Fundamentals of Mathematical Genetics","author":"Edwards","year":"2000"},{"key":"10.1111\/apt.12378-BIB0019|apt12378-cit-0019","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2982.2006.00877.x","article-title":"Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome","volume":"19","author":"Cain","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1111\/apt.12378-BIB0020|apt12378-cit-0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/109980040000200203","article-title":"Comparison of autonomic nervous system indices based on abdominal pain reports in women with irritable bowel syndrome","volume":"2","author":"Burr","year":"2000","journal-title":"Biol Res Nurs"},{"key":"10.1111\/apt.12378-BIB0021|apt12378-cit-0021","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1136\/gut.2003.017962","article-title":"Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress","volume":"53","author":"Posserud","year":"2004","journal-title":"Gut"},{"key":"10.1111\/apt.12378-BIB0022|apt12378-cit-0022","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0049-0172(00)80010-4","article-title":"Autonomic dysfunction in patients with fibromyalgia: application of power spectral analysis of heart rate variability","volume":"29","author":"Cohen","year":"2000","journal-title":"Semin Arthritis Rheum"},{"key":"10.1111\/apt.12378-BIB0023|apt12378-cit-0023","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/gast.2001.27995","article-title":"Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology","volume":"121","author":"Levy","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1111\/apt.12378-BIB0024|apt12378-cit-0024","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/j.1572-0241.1998.440_j.x","article-title":"Evidence of a genetic contribution to functional bowel disorder","volume":"93","author":"Morris-Yates","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1111\/apt.12378-BIB0025|apt12378-cit-0025","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/gut.2003.030882","article-title":"Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders","volume":"53","author":"Kim","year":"2004","journal-title":"Gut"},{"key":"10.1111\/apt.12378-BIB0026|apt12378-cit-0026","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/gut.52.1.91","article-title":"Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?","volume":"52","author":"Gonsalkorale","year":"2003","journal-title":"Gut"},{"issue":"12 Suppl","key":"10.1111\/apt.12378-BIB0027|apt12378-cit-0027","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.amjmed.2009.09.008","article-title":"Pathophysiology of fibromyalgia","volume":"122","author":"Bradley","year":"2009","journal-title":"Am J Med"},{"key":"10.1111\/apt.12378-BIB0028|apt12378-cit-0028","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11894-005-0018-9","article-title":"Symptom overlap and comorbidity of irritable bowel syndrome with other conditions","volume":"7","author":"Frissora","year":"2005","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1111\/apt.12378-BIB0029|apt12378-cit-0029","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jpain.2008.12.006","article-title":"Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder","volume":"10","author":"Light","year":"2009","journal-title":"J Pain"},{"key":"10.1111\/apt.12378-BIB0030|apt12378-cit-0030","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1212\/WNL.0b013e3182535d20","article-title":"Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society","volume":"78","author":"Silberstein","year":"2012","journal-title":"Neurology"},{"key":"10.1111\/apt.12378-BIB0031|apt12378-cit-0031","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000198627","article-title":"Timolol treatment in the irritable bowel syndrome","volume":"22","author":"Fielding","year":"1981","journal-title":"Digestion"},{"key":"10.1111\/apt.12378-BIB0032|apt12378-cit-0032","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0140-6736(88)91056-2","article-title":"Atenolol in irritable bowel syndrome","volume":"1","author":"McIntyre","year":"1988","journal-title":"Lancet"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12378","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/apt.12378\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T23:59:49Z","timestamp":1645833589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,8]]}},"URL":"https:\/\/doi.org\/10.1111\/apt.12378","relation":{},"ISSN":["0269-2813"],"issn-type":[{"value":"0269-2813","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}