{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:41:43Z","timestamp":1788306103260,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T00:00:00Z","timestamp":1380931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current diagnostic guidelines recommend that eosinophilic oesophagitis (EoE) should be diagnosed only after <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> is excluded by a lack of response to a trial of acid suppression. There is limited information available providing outcome data about the effectiveness of this approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the impact of double\u2010dose proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) therapy on symptoms, endoscopic and histological features in patients with documented oesophageal eosinophilia consistent with EoE (\u226515 eosinophils\/high\u2010power field).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty consecutive symptomatic patients with documented oesophageal eosinophilia received open\u2010label omeprazole 20\u00a0mg orally twice daily before meals for 8\u00a0weeks. Clinical, endoscopic and histological (resolution: 0\u20135 eosinophils\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>, partial improvement: 5\u201314 eosinophils\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>), or no improvement: (\u226515 eosinophils\/<jats:styled-content style=\"fixed-case\">HPF<\/jats:styled-content>) evaluation was repeated at the end of this period. An expert <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> pathologist, unaware of the study aims, reviewed all slides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical improvement occurred in 43 (71.6%), endoscopic signs were reduced in 34 (61.8%) and normalised in 12 (21.8%), and histologically, 34 (56.6%) improved, while 15 (25%) obtained complete resolution. Overall, 22 patients (36.7%) obtained both complete clinical and histological remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than 50% of patients with documented oesophageal eosinophilic infiltration in the EoE range improved when treated with a double\u2010dose <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> trial for 8\u00a0weeks. These findings support the published guidelines recommending a <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> trial prior to diagnosing EoE, and confirm the existence of an eosinophilic oesophageal infiltration<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010responsive population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12513","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:18:58Z","timestamp":1381544338000},"page":"1312-1319","source":"Crossref","is-referenced-by-count":72,"title":["The outcome of patients with oesophageal eosinophilic infiltration after an eight\u2010week trial of a proton pump inhibitor"],"prefix":"10.1111","volume":"38","author":[{"given":"G.","family":"Vazquez\u2010Elizondo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ngamruengphong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Khrisna","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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