{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:17:26Z","timestamp":1762928246312},"reference-count":166,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are patients with chronic hepatitis C who are not eligible for the current interferon\u2010based therapies or refuse to be treated due to secondary effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide information on alternative treatments for the management of these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A PubMed search was performed to identify relevant literature. Search terms included hepatitis C virus, anti\u2010inflammatory treatment, antioxidant, natural products and alternative treatment, alone or in combination. Additional publications were identified using the references cited by primary and review articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several approaches, such as iron depletion (phlebotomy), treatment with ursodeoxycholic acid or glycyrrhizin, have anti\u2010inflammatory and\/or anti\u2010fibrotic effects. Life interventions like weight loss, exercise and coffee consumption are associated with a biochemical improvement. Other alternatives (ribavirin monotherapy, amantadine, silibinin, vitamin supplementation, etc.) do not have any beneficial effect or need to be tested in larger clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are therapeutic strategies and lifestyle interventions that can be used to improve liver damage in patients with chronic hepatitis C who cannot receive or refuse interferon\u2010based treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12562","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T03:33:01Z","timestamp":1385523181000},"page":"148-162","source":"Crossref","is-referenced-by-count":14,"title":["Review article: management of chronic hepatitis C in patients with contraindications to anti\u2010viral therapy"],"prefix":"10.1111","volume":"39","author":[{"given":"V.","family":"Carre\u00f1o","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Estudio Hepatitis Virales Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.653341"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12080"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/0016-5085(92)90339-Z","article-title":"Measurements of iron status in patients with chronic hepatitis","volume":"102","author":"Biscesglie AM","year":"1992","journal-title":"Gastroenterology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04759.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-923315"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(93)92127-L"},{"key":"e_1_2_8_9_1","first-page":"986","article-title":"Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron","volume":"89","author":"Hayashi H","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80278-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1996.tb00737.x"},{"key":"e_1_2_8_12_1","first-page":"241","article-title":"Effect of blood letting on serum aminotransferase levels of patients with chronic hepatitis C and iron overload","volume":"89","author":"Girelli CM","year":"1998","journal-title":"Recenti Prog Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(01)80072-4"},{"key":"e_1_2_8_14_1","first-page":"8697","article-title":"Normalization of elevated hepatic 8\u2010hydroxy\u20102'\u2010deoxyguanosine levels in chronic hepatitis C patients by phlebotomy and low iron diet","volume":"61","author":"Kato J","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1344-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9076-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.4088"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1967-y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2095-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i5.596"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05436.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6085"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328349923c"},{"key":"e_1_2_8_24_1","first-page":"G439","article-title":"Iron absorption in normal and iron\u2010deficient beagle dogs: mucosal iron kinetics","volume":"249","author":"Nathanson MH","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_8_25_1","first-page":"563","article-title":"Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C","volume":"52","author":"Kimura F","year":"2005","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(99)00084-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36088"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200303"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(94)80001-4"},{"key":"e_1_2_8_30_1","first-page":"151","article-title":"Effects of ursodeoxycholic acid on serum liver enzymes in patients with hepatitis C virus\u2010related chronic liver disease","volume":"7","author":"Puoti C","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1995.tb01596.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199713040-00003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.1999.tb00066.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(98)00099-0"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.120956"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2782"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00406.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50018"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1158\/1055-9965.164.14.1","article-title":"Ursodiol use is possibly associated with lower incidence of hepatocellular carcinoma in hepatitis C virus\u2010associated liver cirrhosis","volume":"14","author":"Tarao K","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91707-2"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160307"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890410203"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-12-199512150-00001"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80225-X"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260231"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.1998.00099.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.1996.tb00050.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280132"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80550-1"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50258"},{"key":"e_1_2_8_51_1","first-page":"CD002148","article-title":"Colchicine for alcoholic and non\u2010alcoholic liver fibrosis and cirrhosis","volume":"2","author":"Rambaldi A","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018857314351"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1086\/319220"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2004.30057.x"},{"key":"e_1_2_8_55_1","first-page":"1911","article-title":"Amantadine in non\u2010responder patients with chronic hepatitis C: a randomized prospective study","volume":"59","author":"Palabiyikoglu M","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22269"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1222"},{"key":"e_1_2_8_58_1","first-page":"15","article-title":"Current perspectives on rosuvastatin","volume":"6","author":"Hu M","year":"2013","journal-title":"Integrated Blood Pressure Control"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0959-1"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21554"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01876.x"},{"key":"e_1_2_8_62_1","first-page":"1704","article-title":"Lovastatin and fluvastatin reduce viremia and the pro\u2010inflammatory cytokines in the patients with chronic hepatitis C","volume":"56","author":"Mih\u0103il\u0103 R","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5020"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240010"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.015"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831040-00006"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.014"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200502000-00002"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031516"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2415"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14034705"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04371.x"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31357-2"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322499"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769709097863"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/1071576031000102141"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04937.x"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.73.6.411"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2012.03.004"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000231746.76136.4a"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21292"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000174023.73472.29"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i40.5317"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i2.184"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510004629"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02604.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015492"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199816040-00004"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i21.2638"},{"key":"e_1_2_8_90_1","doi-asserted-by":"crossref","first-page":"e000140","DOI":"10.1136\/bmjopen-2011-000140","article-title":"Viusid, a nutritional supplement, increases survival and reduces disease progression in HCV\u2010related decompensated cirrhosis: a randomised and controlled trial","volume":"1","author":"Vilar Gomez E","year":"2011","journal-title":"BMJ Open"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70134-X"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840380412"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290429"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1996.tb00729.x"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05460.x"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.87"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068992"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970415)79:8<1494::AID-CNCR8>3.0.CO;2-B"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.02008.x"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04049.x"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.015"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01579.x"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00002"},{"key":"e_1_2_8_104_1","first-page":"2221","article-title":"Reduction therapy of alanine aminotransferase levels prevent HCC development in patients with HCV\u2010associated cirrhosis","volume":"26","author":"Rino Y","year":"2006","journal-title":"Anticancer Res"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1159\/000048283"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600641365"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-3177-0"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00199.x"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02382.x"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0034-x"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(02)00332-7"},{"key":"e_1_2_8_112_1","first-page":"127","article-title":"Clinical and laboratory observation on the effect of glycyrrhizin in acute and chronic viral hepatitis","volume":"4","author":"Xianshi S","year":"1984","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.02.038"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23587"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914009107"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.053"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-153"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016464"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.06.015"},{"key":"e_1_2_8_120_1","first-page":"68","article-title":"Oral silymarin for chronic hepatitis C \u2013 a retrospective analysis comparing three dose regimens","volume":"10","author":"Huber R","year":"2005","journal-title":"Eur J Med Res"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04138.x"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009347475"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.8265"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.017566"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.072"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1942"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01572.x"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.11.035"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24610"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24803"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1304-0"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b12-00251"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.06.001"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2011.08.035"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.011"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.004945"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1096"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-32"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.03.007"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1404-z"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04320.x"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.04.008"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000135372.10846.2a"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80287-5"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22940"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23276"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.89"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.027581"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.13.6213"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00833.x"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.011"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2010.09.001"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-012-1034-0"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.019"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701272409"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.jcbn08-246"},{"key":"e_1_2_8_157_1","first-page":"178","article-title":"Zinc supplementation therapy improves the outcome of patients with chronic hepatitis C","volume":"51","author":"Matsumura H","year":"2012","journal-title":"J Clin Biochem Nutr"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50046"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2004.0928.x"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.2.248"},{"key":"e_1_2_8_161_1","first-page":"61","article-title":"Role of hemochromatosis genes in chronic hepatitis C","volume":"157","author":"Gattoni A","year":"2006","journal-title":"Clin Ter"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23162"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23279"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.08.027"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.069"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2008.05.009"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902803515"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12562","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T08:43:41Z","timestamp":1696495421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":166,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/apt.12562"],"URL":"https:\/\/doi.org\/10.1111\/apt.12562","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]}}}