{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:59:15Z","timestamp":1788263955579,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Staging of liver fibrosis in patients with chronic hepatitis C (CHC) is recommended prior to anti\u2010viral therapy. As <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag was shown as a predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis, we performed this study to investigate if <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag is able to predict different fibrosis stages and if it is comparable to other fibrosis scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate if <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag is able to predict different fibrosis stages and if it is comparable to other fibrosis scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 294 patients with chronic hepatitis C who underwent biopsy. We assessed stage of liver fibrosis according to Metavir, measured <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag and calculated different fibrosis scores (APRI, FCI, FORNS, FI, Fib\u20104) and compared them by AUCs. We also calculated a new score: <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag\/thrombocytes (VITRO score) for prediction of fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag levels were increasing with stage of fibrosis: F0: <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag was median 136.5%, FI 140.6%, FII 157.5%, FIII 171.0%, FIV 252.0%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001. <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag and VITRO score produced AUCs of 0.7 and 0.72 for \u2265F2, comparable to the AUCs of APRI, Fib\u20104, FORNS with 0.75, 0.65 and 0.64 (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). For \u2265F3 AUCs were 0.79 and 0.86 for <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag and VITRO score, comparable with AUCs of 0.79, 0.86 and 0.87 for APRI, Fib\u20104 and FORNS. Cirrhosis shows AUCs of 0.84 and 0.89 for <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag and VITRO score, APRI, Fib\u20104 and FORNS showed similar results with AUCs of 0.82, 0.88 and 0.87.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag and VITRO score offer an easy possibility to evaluate the stage of fibrosis to diagnose subclinical cirrhosis in patients with chronic hepatitis C. Both <jats:styled-content style=\"fixed-case\">vWF<\/jats:styled-content>\u2010Ag and VITRO score show equal performance in comparison to other fibrosis scores assessed in our study. <\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12564","type":"journal-article","created":{"date-parts":[[2013,12,6]],"date-time":"2013-12-06T02:42:41Z","timestamp":1386297761000},"page":"331-338","source":"Crossref","is-referenced-by-count":58,"title":["Von Willebrand Factor as a new marker for non\u2010invasive assessment of liver fibrosis and cirrhosis in patients with chronic hepatitis C"],"prefix":"10.1111","volume":"39","author":[{"given":"A.","family":"Maieron","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Internal Medicine IV Elisabeth Hospital Linz Linz Austria"},{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Salzl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peck\u2010Radosavljevic","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Trauner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hametner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Internal Medicine IV Elisabeth Hospital Linz Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sch\u00f6fl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Internal Medicine IV Elisabeth Hospital Linz Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ferenci","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferlitsch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine III Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01934.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70216-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832922"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604301"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012912"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010494"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"2","article-title":"2011 European Association of the Study of the Liver hepatitis C virus clinical practice guidelines","volume":"32","author":"European Association of the Study of the Liver","year":"2012","journal-title":"Liver Int"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.04.035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i23.3682"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000071293"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24671"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.02.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-44"},{"key":"e_1_2_7_16_1","first-page":"77","article-title":"Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level","volume":"60","author":"Ohta T","year":"2006","journal-title":"Acta Med Okayama"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00838.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25806"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1317"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230613"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.1.179.413k18_179_185"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.02.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21228"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840210505"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.235689"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.235689"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.04.035"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21231"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1654"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.058"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02785.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.16602"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02305.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.06.031"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-91"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36128"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/153986"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20534"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2003.09.022"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.044"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04500.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12564","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:36:48Z","timestamp":1695497808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,5]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/apt.12564"],"URL":"https:\/\/doi.org\/10.1111\/apt.12564","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,5]]}}}