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In addition, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> is the main cause of hepatocellular cancer (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>. Recent developments in the diagnosis and treatment of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, including new recommendations pertaining to screening for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> by the Centers for Disease Control and Prevention and newer treatment regimens with high efficacy, short duration and the potential for interferon\u2010free therapies, have energised the health care practitioners regarding <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the full impact of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> burden on clinical, economic and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An expert panel was convened to assess the full impact of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> burden on a number of important outcomes using an evidence\u2010based approach predicated on Grading of Recommendations Assessment, Development and Evaluation methodology. The literature was summarised, graded using an evidence\u2010based approach and presented during the workshop. Workshop presentations were intended to review recent, relevant evidence\u2010based literature and provide graded summary statements pertaining to <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> burden on topics including the relationships between <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and the development of important outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The associations of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> with cirrhosis, <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, liver\u2010related mortality, type 2 diabetes mellitus, rheumatological diseases and quality of life impairments are supported by strong evidence. Also, there is strong evidence that sustained viral eradication of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> can improve important outcomes such as mortality and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current evidence suggests that <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> has been associated with tremendous clinical, economic and quality of life burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12625","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T01:23:02Z","timestamp":1390785782000},"page":"518-531","source":"Crossref","is-referenced-by-count":107,"title":["The impact of hepatitis C burden: an evidence\u2010based approach"],"prefix":"10.1111","volume":"39","author":[{"given":"Z. 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