{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:56:56Z","timestamp":1793408216776,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T00:00:00Z","timestamp":1390694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Some patients with a phenotypic appearance of eosinophilic oesophagitis (EoE) respond histologically to <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>, and are described as having <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010responsive oesophageal eosinophilia (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>). It is unclear if <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> is a <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\u2010related phenomenon, a subtype of EoE, or a completely unique entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare demographic, clinical and histological features of EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two databases were reviewed from the Walter Reed and Swiss EoE databases. Patients were stratified into two groups, EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>, based on recent EoE consensus guidelines. Response to <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> was defined as achieving less than 15\u00a0eos\/hpf and a 50% decrease from baseline following at least a 6\u2010week course of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and three patients were identified (63 EoE and 40 <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>; mean age 40.2\u00a0years, 75% male and 89% Caucasian). The two cohorts had similar dysphagia (97% vs. 100%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.520), food impaction (43% vs. 35%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.536), and heartburn (33% vs. 32%, <jats:italic>P\u00a0<\/jats:italic>=\u00a01.000) and a similar duration of symptoms (6.0\u00a0years vs. 5.8\u00a0years, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.850). Endoscopic features were also similar between EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>; rings (68% vs. 68%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.000), furrows (70% vs. 70%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.000), plaques (19% vs. 10%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.272), strictures (49% vs. 30%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.066). EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content> were similar in the number of proximal (39\u00a0eos\/hpf vs. 38\u00a0eos\/hpf, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.919) and distal eosinophils (50 vs. 43\u00a0eos\/hpf, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.285).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EoE and <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\u2010responsive oesophageal eosinophilia are similar in clinical, histological and endoscopic features and therefore are indistinguishable without a <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> trial. Further studies are needed to determine why a subset of patients with oesophageal eosinophilia respond to <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12636","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T01:21:53Z","timestamp":1390785713000},"page":"603-608","source":"Crossref","is-referenced-by-count":103,"title":["Eosinophilic oesophagitis and proton pump inhibitor\u2010responsive oesophageal eosinophilia have similar clinical, endoscopic and histological findings"],"prefix":"10.1111","volume":"39","author":[{"given":"F. J.","family":"Moawad","sequence":"first","affiliation":[{"name":"Gastroenterology Service Department of Medicine Walter Reed National Military Medical Center Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Schoepfer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Safroneeva","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Ally","sequence":"additional","affiliation":[{"name":"Gastroenterology Service Department of Medicine Walter Reed National Military Medical Center Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Gastroenterology Service Department of Medicine Walter Reed National Military Medical Center Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Maydonovitch","sequence":"additional","affiliation":[{"name":"Gastroenterology Service Department of Medicine Walter Reed National Military Medical Center Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K. H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Gastroenterology Service Department of Medicine Walter Reed National Military Medical Center Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i32.4335"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01594.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.443"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.459"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12332"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.363"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03739.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04476.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.06.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00562.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00313-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.042"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04922.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12513"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01179.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04018.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.023"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302250"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(13)61793-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1991-5"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12636","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:48:29Z","timestamp":1696528109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,26]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/apt.12636"],"URL":"https:\/\/doi.org\/10.1111\/apt.12636","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,26]]}}}