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A systemic inflammatory response is a pathogenetic factor in advanced disease. Such physiological changes render the individual vulnerable to further deterioration of renal function. Patients are primed to develop acute kidney injury when exposed to additional \u2018hits\u2019, such as sepsis. Recent progress has been made regarding our understanding of the aetiopathogenesis. However, treatment options once hepatorenal syndrome develops are limited, and prognosis remains poor. Various strategies to prevent acute kidney injury are suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prevention of acute kidney injury in high risk patients with cirrhosis and portal hypertension\u2010related renal dysfunction should be a clinical priority.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12653","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T09:47:34Z","timestamp":1392630454000},"page":"699-711","source":"Crossref","is-referenced-by-count":19,"title":["Review article: advances in the management of patients with cirrhosis and portal hypertension\u2010related renal dysfunction"],"prefix":"10.1111","volume":"39","author":[{"given":"J. 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