{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:55:46Z","timestamp":1790740546260,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been encouraging reports on transjugular intrahepatic portosystemic stent\u2010shunt (<jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content>) for Budd\u2013Chiari syndrome (<jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content>). Long\u2010term data are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess long\u2010term outcomes and validate prognostic scores following <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single centre retrospective study. Patients underwent <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> using bare or polytertrafluoroethane (<jats:styled-content style=\"fixed-case\">PTFE<\/jats:styled-content>)\u2010covered stents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven patients received successful <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> between 1996 and 2012 using covered (<jats:italic>n\u00a0<\/jats:italic>=\u00a040) or bare (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) stents. Patients included had a Male: Female ratio of 21:46, and were characterised (mean\u00a0\u00b1\u00a0s.d.) by age 39.9\u00a0\u00b1\u00a014.3\u00a0years, Model of end stage liver disease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>) 16.1\u00a0\u00b1\u00a07.0 and Child's score 8.8\u00a0\u00b1\u00a02.0. Seventy\u2010eight percent had haematological risk factors. Presenting symptoms were ascites (<jats:italic>n<\/jats:italic>\u00a0=\u00a061) and variceal bleeding (<jats:italic>n<\/jats:italic>\u00a0=\u00a06). Nine patients underwent hepatic vein dilatation or stenting prior to <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content>. Mean follow\u2010up was 82\u00a0months (range 0.5\u2013184\u00a0months). Fifteen percent had post\u2010<jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> encephalopathy. Two have been transplanted. Primary patency rates (76% vs. 27%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and shunt re\u2010interventions (22% vs. 100%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) significantly favoured covered stents. Secondary patency was 99%. Six\u2010, 12\u2010, 24\u2010, 60\u2010 and 120\u2010month survival was 97%, 92%, 87%, 80% and 72% respectively. Six patients had liver related deaths. Two patients developed hepatocellular carcinoma. The <jats:styled-content style=\"fixed-case\">BCS TIPS PI<\/jats:styled-content> independently predicted mortality in the whole cohort, but no prognostic score was a significant predictor of mortality after subgroup validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term outcomes following <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">Budd\u2013Chiari syndrome<\/jats:styled-content> are very good. <jats:styled-content style=\"fixed-case\">PTFE<\/jats:styled-content>\u2010covered stents have significantly better primary patency. The value of prognostic scores is controversial. <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content> should be considered as first line therapy in symptomatic patients in whom hepatic vein patency cannot be restored.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12668","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:12:07Z","timestamp":1393265527000},"page":"864-872","source":"Crossref","is-referenced-by-count":100,"title":["Good clinical outcomes following transjugular intrahepatic portosystemic stent\u2010shunts in Budd\u2013Chiari syndrome"],"prefix":"10.1111","volume":"39","author":[{"given":"D.","family":"Tripathi","sequence":"first","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"MacNicholas","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Birmingham 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