{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:05:56Z","timestamp":1791515156079,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Microscopic colitis, comprising collagenous colitis (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) and lymphocytic colitis (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>), is a common cause of chronic diarrhoea. The long\u2010term prognosis is not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study outcome of symptoms and health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study using a postal questionnaire with three population\u2010based controls per patient matched for age, sex and municipality. <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL was assessed by the Short Health Scale (<jats:styled-content style=\"fixed-case\">SHS<\/jats:styled-content>). Patients in clinical remission, defined as a mean of &lt;3 stools\/day, were evaluated separately (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a072, <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a060).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 212 patients and 627 matched controls. Median disease duration was 5.9 (range 0.5\u201327) years and 6.4 (0.3\u201314.8) years for <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> respectively. Abdominal pain, fatigue, arthralgia, myalgia, faecal incontinence and nocturnal defecation were significantly more prevalent in <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> patients compared with controls. These differences persisted in <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> patients in clinical remission with respect to abdominal pain (36% vs. 21%), fatigue (54% vs. 34%), arthralgia (61% vs. 41%) and myalgia (53% vs. 37%). In <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients, abdominal pain, fatigue, faecal incontinence and nocturnal defecation were more prevalent compared with controls. In <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> patients in clinical remission, fatigue was more prevalent compared with controls (54% vs. 37%). These differences were statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). All four <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL dimensions (symptom burden, social function, disease\u2010related worry, general well\u2010being) were impaired in patients with active <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although considered to be in clinical remission, patients with microscopic colitis suffer from persisting symptoms such as abdominal pain, fatigue, arthralgia or myalgia several years after diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12685","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T05:23:50Z","timestamp":1394515430000},"page":"963-972","source":"Crossref","is-referenced-by-count":72,"title":["Long\u2010term prognosis of clinical symptoms and health\u2010related quality of life in microscopic colitis: a case\u2013control study"],"prefix":"10.1111","volume":"39","author":[{"given":"N.","family":"Nyhlin","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wickbom","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Clinical Epidemiology and Biostatistics \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"The Clinical Epidemiology Unit Karolinska University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tysk","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"School of Health and Medical Sciences \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bohr","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Gastroenterology \u00d6rebro University Hospital \u00d6rebro Sweden"},{"name":"School of Health and Medical Sciences \u00d6rebro 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