{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:14:12Z","timestamp":1790367252405,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) may potentially modify and decrease the risk for development of oesophageal adenocarcinoma in Barrett's oesophagus (<jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate if the intensity and adherence of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> use among all patients with <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content> in Denmark affected the risk of oesophageal adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a nationwide case\u2013control study in Denmark among 9883 patients with a new diagnosis of <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>. All incident oesophageal adenocarcinomas and high\u2010grade dysplasias were identified, and risk ratios were estimated on the basis of prior use of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s. Sex\u2010 and age\u2010matched <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content> patients without dysplasia or malignancies in a 10:1 ratio were used for comparison. Conditional logistic regression was used for analysis, adjusting for low\u2010grade dysplasia, gender and medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 140 cases with incident oesophageal adenocarcinomas and\/or high\u2010grade dysplasia, with a median follow\u2010up time of 10<jats:bold>.<\/jats:bold>2\u00a0years. The relative risk of oesophageal adenocarcinoma or high\u2010grade dysplasia was 2.2 (0.7\u20136.7) and 3.4 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.1\u201310.5) in long\u2010term low\u2010 and high\u2010adherence <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> users respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No cancer\u2010protective effects from <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>'s were seen. In fact, high\u2010adherence and long\u2010term use of <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> were associated with a significantly increased risk of adenocarcinoma or high\u2010grade dysplasia. This could partly be due to confounding by indication or a true negative effect from <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s. Until the results from future studies hopefully can elucidate the association further, continuous <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy should be directed at symptom control and additional modalities considered as aid or replacement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12693","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T03:00:38Z","timestamp":1394593238000},"page":"984-991","source":"Crossref","is-referenced-by-count":91,"title":["Proton pump inhibitor use may not prevent high\u2010grade dysplasia and oesophageal adenocarcinoma in Barrett's oesophagus: a nationwide study of 9883 patients"],"prefix":"10.1111","volume":"39","author":[{"given":"F.","family":"Hvid\u2010Jensen","sequence":"first","affiliation":[{"name":"Department of Surgical Gastroenterology L Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Funch\u2010Jensen","sequence":"additional","affiliation":[{"name":"Aleris\u2010Hamlet Hospital and Institute of Clinical Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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