{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:08:16Z","timestamp":1784750896469,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increasing bolus viscosity of thin liquids is a basic therapeutic strategy to protect patients with oropharyngeal dysphagia (<jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content>) from aspiration. However, conventional starch thickeners increase post\u2010deglutitive residue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the therapeutic effect of a new xanthan gum\u2010based thickener, Resource ThickenUp Clear (Nestl\u00e9 Health Science, Vevey, Switzerland) on patients with oropharyngeal dysphagia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the effect of Resource ThickenUp Clear using a clinical method and videofluoroscopy on 120 patients with oropharyngeal dysphagia (66 with stroke, 41 older and 13 with neurodegenerative diseases) and 14 healthy volunteers while swallowing thin\u2010liquid, nectar\u2010like and spoon\u2010thick boluses. We assessed the prevalence of signs of impaired safety and efficacy of swallow and the physiology of the swallow response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increasing bolus viscosity with Resource ThickenUp Clear: (i) improved safety of swallow demonstrated by a reduction in the prevalence of cough and voice changes in the clinical study and penetrations and aspirations during video fluoroscopy. Prevalence of aspirations was 12.7% with thin liquid, 7.7% with nectar\u2010like (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and 3.4% with spoon\u2010thick (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) viscosities. Penetration\u2013Aspiration Scale was reduced from 3.24\u00a0\u00b1\u00a00.18 at thin liquid to 2.20\u00a0\u00b1\u00a00.18 at nectar\u2010like (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and to 1.53\u00a0\u00b1\u00a00.13 at spoon\u2010thick (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) viscosities; (ii) did not enhance pharyngeal residue; (iii) nectar\u2010like viscosity did not affect bolus velocity nor timing of swallow response and (iv) spoon\u2010thick viscosity reduced bolus velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resource ThickenUp Clear improves the safety of swallow without increasing residue providing a viscosity\u2010dependent therapeutic effect for patients with oropharyngeal dysphagia. At nectar viscosity, the effect is due to intrinsic texture properties, spoon\u2010thick viscosity adding changes in swallow physiology. <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01158313.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12696","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T03:14:17Z","timestamp":1394766857000},"page":"1169-1179","source":"Crossref","is-referenced-by-count":149,"title":["The effects of a xanthan gum\u2010based thickener on the swallowing function of patients with dysphagia"],"prefix":"10.1111","volume":"39","author":[{"given":"L.","family":"Rofes","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de enfermedades hep\u00e1ticas y digestivas (CIBERehd) Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Arreola","sequence":"additional","affiliation":[{"name":"Unitat de Proves Funcionals Digestives Department de Cirurgia Hospital de Matar\u00f3 Universitat Aut\u00f2noma de Barcelona Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Research Center Nestec Ltd Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 R&amp;D Center Nestec Ltd Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Clav\u00e9","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de enfermedades hep\u00e1ticas y digestivas (CIBERehd) Instituto de Salud Carlos III Barcelona Spain"},{"name":"Unitat de Proves Funcionals Digestives Department de Cirurgia Hospital de Matar\u00f3 Universitat Aut\u00f2noma de Barcelona Matar\u00f3 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"ICD\u201010 Version:2010 [Homepage on the Internet]","author":"World Health Organization","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01521.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000190056.76543.eb"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000046586.38284.60"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp100"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00019012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt099"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03118.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59980300633-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02406920"},{"key":"e_1_2_7_13_1","first-page":"G675","article-title":"Effect of swallowed bolus variables on oral and pharyngeal phases of swallowing","volume":"258","author":"Dantas RO","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00714593"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360(2005\/003)"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-012-9441-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/asi.21523"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339979"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_7_21_1","volume-title":"National Dysphagia Diet: standardization for Optimal Care","author":"National Dysphagia Diet Task Force","year":"2002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-009-9239-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-006-9069-9"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.08.009"}],"container-title":["Alimentary Pharmacology &amp; 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