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Complete laboratory resolution and reversion to normal liver tissue prior to drug withdrawal favours this response. The development of cirrhosis during therapy may increase treatment\u2010dependence. Persistent liver damage and the generation of neo\u2010antigens during the apoptosis of hepatocytes may perpetuate the disease. Genetic and age\u2010related effects on the vigour of the immune response may also contribute. Reversion to normal liver tissue is achieved in only 22% of patients during conventional corticosteroid therapy, and the emerging pharmacological and biological interventions may improve this frequency. A management strategy designed to achieve a treatment\u2010free state accommodates all candidates for this outcome, and it can be modified to a long\u2010term maintenance strategy as warranted by the clinical response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Permanent drug withdrawal is a treatment outcome that is desirable and achievable in patients with autoimmune hepatitis. Normalisation of liver tests and liver tissue during treatment enhances this occurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12701","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T03:14:29Z","timestamp":1394766869000},"page":"1043-1058","source":"Crossref","is-referenced-by-count":34,"title":["Review article: permanent drug withdrawal is desirable and achievable for autoimmune hepatitis"],"prefix":"10.1111","volume":"39","author":[{"given":"A. 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