{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:59:06Z","timestamp":1761947946773},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Faecal short chain fatty acids (<jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content>s) are produced by the gut microflora. We have previously reported high faecal <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content> levels in children with coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>), indicating alteration in gut microfloral metabolism. Data accumulated over recent decades by us and others suggest that wheat\u2010free oats can safely be included in a gluten\u2010free diet (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>). However, concerns have been raised with respect to the safety of oats in a subset of coeliacs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe faecal <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content> patterns in children with newly diagnosed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> treated for 1\u00a0year with a <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> with or without oats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This report is part of a randomised, double\u2010blind study on the effect of a <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> containing oats (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010oats) vs. a standard <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010std). Faecal samples were received from 34 children in the <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010oats group and 37 in the <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010std group at initial diagnosis and\/or after 1\u00a0year on a <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>. Faecal <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content>s were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010std group had a significantly lower total faecal <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content> concentration at 12\u00a0months compared with 0\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In contrast, total <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010oats group remained high after 1\u00a0year on the <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>. The children in the <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010oats group had significantly higher acetic acid (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), <jats:italic>n<\/jats:italic>\u2010butyric acid (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and total <jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content> concentration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) after 1\u2010year diet treatment compared to the <jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>\u2010std group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that oats do affect the gut microflora function, and that some coeliac children receiving oats may develop gut mucosal inflammation, that may present a risk for future complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12707","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T05:02:51Z","timestamp":1395723771000},"page":"1156-1160","source":"Crossref","is-referenced-by-count":19,"title":["The effects of oats on the function of gut microflora in children with coeliac disease"],"prefix":"10.1111","volume":"39","author":[{"given":"B.","family":"Tjellstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology Karolinska Institute Stockholm Sweden"},{"name":"Department of Paediatrics Norrk\u00f6ping Hospital County Council of \u00d6sterg\u00f6tland Norrk\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Stenhammar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Norrk\u00f6ping Hospital County Council of \u00d6sterg\u00f6tland Norrk\u00f6ping Sweden"},{"name":"Division of Paediatrics Department of 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