{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:41:11Z","timestamp":1770835271211,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T00:00:00Z","timestamp":1396828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased numbers of duodenal intraepithelial lymphocytes (IELs) characterise coeliac disease (CD) but have also been described in noncoeliacs. Controversy exists regarding an association between increased IELs and infection with <jats:italic>Helicobacter pylori<\/jats:italic>, which is commonly found in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the relationship between <jats:italic>H. pylori<\/jats:italic> infection and duodenal IELs in a large cohort of children, with and without CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed gastric and duodenal biopsies of children who underwent esophagogastroduodenoscopy between January 2006 and February 2013 because of either recurrent abdominal pain (RAP) or suspected CD at Schneider Children's Medical Center of Israel, a referral centre for Israel's largest Health Maintenance Organization. The duodenal IEL count and <jats:italic>H. pylori<\/jats:italic> presence in antral biopsies were determined for each specimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Children with RAP (<jats:italic>n<\/jats:italic>\u00a0=\u00a0693) or CD (<jats:italic>n<\/jats:italic>\u00a0=\u00a0306) were included. Among children with RAP, <jats:italic>H. pylori<\/jats:italic> was present in 33.8%. The mean IEL count in the <jats:italic>H. pylori<\/jats:italic> positive RAP group was 17.8(\u00b18.8)\/100 enterocytes, vs. 15.8(\u00b18.3) in the <jats:italic>H. pylori<\/jats:italic> negative patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). Increased IEL counts (\u226525 IELs\/100 enterocytes) were found in 15.7% of <jats:italic>H. pylori<\/jats:italic> negative, noncoeliac children. Among children with CD, there was no significant difference in IEL counts according to <jats:italic>H. pylori<\/jats:italic> status: 73.1(\u00b126.1) vs. 72.6 (\u00b126.5) in <jats:italic>H. pylori<\/jats:italic> positive and negative patients respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that slightly elevated duodenal intraepithelial lymphocyte counts are common in the paediatric population. <jats:italic>Helicobacter pylori<\/jats:italic> infection has no major influence on the intraepithelial lymphocyte counts in children with recurrent abdominal pain or children with coeliac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12739","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T04:28:39Z","timestamp":1396844919000},"page":"1314-1320","source":"Crossref","is-referenced-by-count":17,"title":["Duodenal intraepithelial lymphocytosis is common in children without coeliac disease, and is not meaningfully influenced by <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"39","author":[{"given":"A.","family":"Guz\u2010Mark","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zevit","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center of Israel Petach Tikva Israel"},{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"The Sackler Faculty of Medicine Tel\u2010Aviv University Petach Tikva Israel"},{"name":"Department of Pathology Rabin Medical Center\u2010 Beilinson Campus Petach Tikva 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