{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:39:59Z","timestamp":1783471199949,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Barrett's oesophagus (BO<\/jats:styled-content>) is a risk factor for oesophageal adenocarcinoma (OAC<\/jats:styled-content>). Several studies report increasing incidences of BO<\/jats:styled-content> with substantial variation.<\/jats:p><\/jats:sec>Aim<\/jats:title>To determine age\u2010 and sex\u2010stratified incidence rates (IR<\/jats:styled-content>) of BO<\/jats:styled-content> and OAC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cohort study using two primary care databases in the United Kingdom (UK<\/jats:styled-content>) and the Netherlands (NL<\/jats:styled-content>) (2000\u20132012). BO<\/jats:styled-content> and OAC<\/jats:styled-content> cases were identified using disease\u2010specific READ<\/jats:styled-content> codes (UK<\/jats:styled-content>) and free\u2010text search with manual validation (NL<\/jats:styled-content>). Age\u2010 and sex\u2010specific incidence rates (IR<\/jats:styled-content>s) were calculated for both BO<\/jats:styled-content> and OAC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>From the study population of 6\u00a0885\u00a0420 subjects in the UK<\/jats:styled-content>, we identified 12\u00a0312 incident BO<\/jats:styled-content> and 40 (0.3%) subsequent incident OAC<\/jats:styled-content> cases. There were 1383 incident BO<\/jats:styled-content>, and subsequent 5 (0.4%) incident OAC<\/jats:styled-content> cases among the 1\u00a0487\u00a0191 subjects in the NL<\/jats:styled-content>. The IR<\/jats:styled-content> of BO<\/jats:styled-content> increased linearly with age: 15.6\/100\u00a0000 PY<\/jats:styled-content>s (UK<\/jats:styled-content>) and 23.7\/100\u00a0000 PY<\/jats:styled-content>s (NL<\/jats:styled-content>) for patients aged 40\u201344\u00a0years, increasing to 85.6\/100\u00a0000 PY<\/jats:styled-content>s (UK<\/jats:styled-content>) and 87.0\/100\u00a0000 PY<\/jats:styled-content>s (NL<\/jats:styled-content>) for 70\u201374\u00a0years. In both the UK<\/jats:styled-content> and the NL<\/jats:styled-content>, IR<\/jats:styled-content> of BO<\/jats:styled-content> was 2\u20134 times higher in males than females across all age groups. With respect to calendar time, the IR<\/jats:styled-content> of BO<\/jats:styled-content> increased by 35% (UK<\/jats:styled-content>) and 41% (NL<\/jats:styled-content>) from 2000 to 2003, after which IR<\/jats:styled-content>s remained stable until 2012.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The incidence rates of BO<\/jats:styled-content> in the UK<\/jats:styled-content> and the NL<\/jats:styled-content> increased until 2003, but levelled off thereafter. Around 0.3% of patients with BO<\/jats:styled-content> developed OAC<\/jats:styled-content> at least 1\u00a0year after BO<\/jats:styled-content> diagnosis. These findings may help tailor endoscopic surveillance strategies among patients with BO<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12759","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T02:41:24Z","timestamp":1397702484000},"page":"1321-1330","source":"Crossref","is-referenced-by-count":45,"title":["The incidence of Barrett's oesophagus and oesophageal adenocarcinoma in the United Kingdom and the Netherlands is levelling off"],"prefix":"10.1111","volume":"39","author":[{"given":"G. M. C.","family":"Masclee","sequence":"first","affiliation":[{"name":"Department of Medical Informatics Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Coloma","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de Wilde","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C. J. M.","family":"Sturkenboom","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Erasmus University Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05669.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.12.020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.028076"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01835.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9596-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600815654"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110684"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.063685"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.304"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63269-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.4.645"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn121"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.10.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103042"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.07.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34748"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.030"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr203"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1335"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1634402"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2532.1994.1130177.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/9.3.330"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051679"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-1-1"},{"key":"e_1_2_7_26_1","first-page":"A6101","article-title":"Summary of the Dutch College of General Practitioners\u2019 (NHG) practice guideline \u2018Gastric symptoms\u2019","volume":"157","author":"Jongh E","year":"2013","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_7_27_1","volume-title":"Clinical Guideline 17. 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