{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:53:06Z","timestamp":1791888786368,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:00:00Z","timestamp":1399420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:00:00Z","timestamp":1399420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The onset of a sprue\u2010like enteropathy in association with olmesartan therapy has been recently reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To perform a systematic review of the literature and describe three additional cases of olmesartan\u2010associated enteropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic and manual bibliographic searches were performed to identify original reports in which subjects who were undertaking olmesartan developed a sprue\u2010like enteropathy. Because of the scarcity of studies with adequate sample size, case series with less than 10 patients and case reports were also considered. Data extraction was performed independently by two reviewers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 11 publications met our pre\u2010defined inclusion criteria, for an overall number of 54 patients (including our series). Almost all patients presented with diarrhoea and weight loss. Normocytic normochromic anaemia and hypoalbuminaemia were the commonest laboratory defects at presentation. Antibody testing for coeliac disease was always negative. Variable degrees of duodenal villous atrophy were present in 98% of patients, while increased intra\u2010epithelial lymphocytes were documented in only 65% of cases. After discontinuation of olmesartan, all reported patients achieved resolution of signs and symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the available evidence is limited, the olmesartan\u2010associated sprue\u2010like enteropathy may be considered as a distinct clinical entity, and should be included in the differential diagnosis when serological testing for coeliac disease is negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12780","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T21:37:10Z","timestamp":1399498630000},"page":"16-23","source":"Crossref","is-referenced-by-count":123,"title":["Systematic review: sprue\u2010like enteropathy associated with olmesartan"],"prefix":"10.1111","volume":"40","author":[{"given":"G.","family":"Ianiro","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Internal Medicine and Gastroenterology School of Medicine and Surgery A. Gemelli Hospital Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bibb\u00f2","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Internal Medicine and Gastroenterology School of Medicine and Surgery A. Gemelli Hospital Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Montalto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Internal Medicine and Gastroenterology School of Medicine and Surgery A. Gemelli Hospital Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Institute of Histopathology School of Medicine and Surgery A. Gemelli Hospital Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Internal Medicine and Gastroenterology School of Medicine and Surgery A. Gemelli Hospital Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cammarota","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Internal Medicine and Gastroenterology School of Medicine and Surgery A. Gemelli Hospital Catholic University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-19"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.45"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00405-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.tb00471.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03423.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.7009"},{"key":"e_1_2_7_8_1","unstructured":"The Seventh Report of the Joint National Committee on Prevention Detection Evaluation and Treatment of High Blood Pressure.Bethesda MD:National Institutes of Health National Heart Lung and Blood Institute US Department of Health and Human Services; 2004. 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