{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:19:12Z","timestamp":1792412352783,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Chronic constipation (\n CC<\/jats:styled-content>\n ) is a highly prevalent health problem, potentially associated with increased risk of colorectal cancer (CRCancer).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To investigate the association between\n CC<\/jats:styled-content>\n , its severity, and\n CRC<\/jats:styled-content>\n ancer by estimating the relative risk of developing\n CRC<\/jats:styled-content>\n ancer and benign colorectal neoplasm (\n BCN<\/jats:styled-content>\n ) among severity\u2010stratified patients with and without\n CC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Chronic constipation patients from a large retrospective\n US<\/jats:styled-content>\n claims database were matched 1:3 with\n CC<\/jats:styled-content>\n \u2010free controls by demographic characteristics.\n CRC<\/jats:styled-content>\n ancer and\n BCN<\/jats:styled-content>\n prevalence were measured over 1\u00a0year. In pre\u2010index\n CRC<\/jats:styled-content>\n ancer\u2010 and\n BCN<\/jats:styled-content>\n \u2010free patients, incidence rate ratios (\n IRR<\/jats:styled-content>\n s) of new\n CRC<\/jats:styled-content>\n ancer and\n BCN<\/jats:styled-content>\n were calculated. Multivariate regression models adjusted for comorbidities and family history.\n CC<\/jats:styled-content>\n patients' disease severity was rated based on\n CC<\/jats:styled-content>\n \u2010related resource use.\n IRR<\/jats:styled-content>\n s for new\n CRC<\/jats:styled-content>\n ancer and\n BCN<\/jats:styled-content>\n were estimated for\n CC<\/jats:styled-content>\n severity groups and controls.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Chronic constipation (\n N<\/jats:italic>\n \u00a0=\u00a028\u00a0854) and\n CC<\/jats:styled-content>\n \u2010free (\n N<\/jats:italic>\n \u00a0=\u00a086\u00a0562) patients had mean age 61.9\u00a0years; 66.7% were female. One\u2010year\n CRC<\/jats:styled-content>\n ancer prevalence was 2.7% and 1.7%, and\n BCN<\/jats:styled-content>\n prevalence was 24.8% and 11.9% for\n CC<\/jats:styled-content>\n and\n CC<\/jats:styled-content>\n \u2010free patients, respectively. Adjusted\n IRR<\/jats:styled-content>\n s between\n CC<\/jats:styled-content>\n and\n CC<\/jats:styled-content>\n \u2010free patients were 1.59 [95% confidence interval (CI): 1.43\u20131.78] and 2.60 [95% CI: 1.51\u20132.70] for\n CRC<\/jats:styled-content>\n ancer and\n BCN<\/jats:styled-content>\n , respectively. Patients with severe and very severe\n CC<\/jats:styled-content>\n had significantly greater incidence of\n CRC<\/jats:styled-content>\n ancer and\n BCN<\/jats:styled-content>\n . At \u22652 and \u22655\u00a0years of observation,\n CRC<\/jats:styled-content>\n ancer and\n BCN<\/jats:styled-content>\n incidence remained consistently and significantly higher for\n CC<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Patients with chronic constipation are associated with significantly higher prevalence and incidence of colorectal cancer and benign colorectal neoplasm than matched chronic constipation\u2010free patients. These risks increase with the severity of chronic constipation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12789","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T05:07:28Z","timestamp":1400216848000},"page":"83-92","source":"Crossref","is-referenced-by-count":107,"title":["Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation"],"prefix":"10.1111","volume":"40","author":[{"given":"A.","family":"Gu\u00e9rin","sequence":"first","affiliation":[{"name":"Analysis Group, Inc. Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mody","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International, Inc. Deerfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Fok","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. 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