{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:02:21Z","timestamp":1792072941843,"version":"4.4.0"},"reference-count":167,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T00:00:00Z","timestamp":1399766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T00:00:00Z","timestamp":1399766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Extraintestinal manifestations are frequent in inflammatory bowel diseases (\n IBD<\/jats:styled-content>\n ). Most studies published so far focused on viral hepatitis and liver toxicity of\n IBD<\/jats:styled-content>\n \u2010related drugs.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To conduct a systematic review of hepatobiliary manifestations associated with\n IBD<\/jats:styled-content>\n . We excluded viral hepatitis and liver toxicity of\n IBD<\/jats:styled-content>\n \u2010related drugs.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Studies were identified through the electronic database of\n MEDLINE<\/jats:styled-content>\n ,\n EMBASE<\/jats:styled-content>\n and the annual meetings of Digestive Disease Week, the American College of Gastroenterology, the United European Gastroenterology Week and the European Crohn's and Colitis Organization.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and forty six articles were included in this systematic review. Cholelithiasis is more frequent in Crohn's disease (\n CD<\/jats:styled-content>\n ) than in general population. Prevalence of cholelithiasis in\n CD<\/jats:styled-content>\n ranged from 11% to 34%, whereas it ranges from 5.5% to 15% in non\u2010\n IBD<\/jats:styled-content>\n patients.\n PSC<\/jats:styled-content>\n is more frequent in\n UC<\/jats:styled-content>\n than in\n CD<\/jats:styled-content>\n . Prevalence of\n PSC<\/jats:styled-content>\n ranges from 0.76% to 5.4% in\n UC<\/jats:styled-content>\n and from 1.2% to 3.4% in\n CD<\/jats:styled-content>\n . There is a male predominance when\n PSC<\/jats:styled-content>\n is associated with\n UC<\/jats:styled-content>\n , with a male\/female ratio ranging from 65\/35 to 70\/30. No conclusion can be made on a possible increased risk of gall\u2010bladder carcinoma. Mean prevalence of fatty liver is 23% (range, 1.5\u201355%). Hepatic amyloidosis occurs in less than 1% of\n IBD<\/jats:styled-content>\n . Liver abscess is encountered mainly in\n CD<\/jats:styled-content>\n . Portal vein thrombosis occurs in 39% to 45% of\n IBD<\/jats:styled-content>\n patients undergoing proctocolectomy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Hepatobiliary manifestations associated with inflammatory bowel diseases are frequent and probably underdiagnosed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12794","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T23:43:07Z","timestamp":1399851787000},"page":"3-15","source":"Crossref","is-referenced-by-count":126,"title":["Systematic review: the epidemiology of the hepatobiliary manifestations in patients with inflammatory bowel disease"],"prefix":"10.1111","volume":"40","author":[{"given":"E.","family":"Gizard","sequence":"first","affiliation":[{"name":"Inserm U954 and Department of Hepato\u2010Gastroenterology University Hospital of Nancy\u2010Brabois Universit\u00e9 de Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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