{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:53:07Z","timestamp":1791888787939,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Use of\n                      <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content>\n                      is associated with increases in ammonia concentration and hepatic encephalopathy (\n                      <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>\n                      ) risk.\n                      <jats:sc>l<\/jats:sc>\n                      \u2010ornithine\u2010\n                      <jats:sc>l<\/jats:sc>\n                      \u2010aspartate (\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      ) is effective in reducing ammonia concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate the effects of\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      on venous ammonia concentration after\n                      <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The included patients were randomised to receive\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      or no\u2010\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      treatment for 7\u00a0days. Fasting and post\u2010prandial venous ammonia levels were the primary outcomes. Psychometric performance, post\u2010\n                      <jats:styled-content style=\"fixed-case\">TIPSS HE<\/jats:styled-content>\n                      , and liver and renal function were assessed as secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 133 cirrhotic patients who received successful\n                      <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content>\n                      between November 2011 and June 2012, 40 met the inclusion criteria and were randomised to the\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021) or control (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019) groups. Change in fasting ammonia significantly favoured the\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      group at days 4 (\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.001) and 7 (\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.003). Changes in post\u2010prandial ammonia concentration significantly favoured the\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      group at days 1, 4 and 7 as well. During the study period, patients in the\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      group had better improvement in psychometric tests than those in the control group. Overt\n                      <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>\n                      during treatment was observed in one patient in the\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      group and three patients in the control group (\n                      <jats:italic>P\u00a0=\u00a0<\/jats:italic>\n                      0.331). There were no differences in complications, adverse events or mortality between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Prophylactic use of\n                      <jats:styled-content style=\"fixed-case\">LOLA<\/jats:styled-content>\n                      infusion after\n                      <jats:styled-content style=\"fixed-case\">TIPSS<\/jats:styled-content>\n                      is safe and effective in significantly reducing the increase of venous ammonia concentration, and can benefit the patient's mental status as well.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12795","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T05:07:57Z","timestamp":1400216877000},"page":"63-71","source":"Crossref","is-referenced-by-count":46,"title":["Randomised clinical trial:\n                    <scp>l<\/scp>\n                    \u2010ornithine\u2010\n                    <scp>l<\/scp>\n                    \u2010aspartate reduces significantly the increase of venous ammonia concentration after\n                    <scp>TIPSS<\/scp>"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Liver Disease and Digestive Interventional Radiology Xijing Hospital of Digestive Diseases Xijing Hospital Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Liver Disease and Digestive Interventional 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