{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:08:05Z","timestamp":1790143685226,"version":"4.0.1"},"reference-count":71,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nonsteroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) include aspirin (acetylsalicylic acid, <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>). Long\u2010term use of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s has been associated with lowered risk of colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>), but the use is hampered by adverse effects. Also, the anti\u2010carcinogenic effects of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s are incompletely understood. Understanding biological effects of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s may help developing new preventive medical strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify gene\u2013environment interactions between genetic variation and <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> use in relation to risk of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a PubMed literature search and all studies reporting original data on interactions between <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s and polymorphisms in relation to <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found indications that aspirin interacted with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"DDBJ\/EMBL\/GenBank\" xlink:href=\"rs6983267\">rs6983267<\/jats:ext-link> close to <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> (encoding a transcription factor involved in cell cycle progression, apoptosis and cellular transformation) and <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s interacted with rs3024505 and rs1800872 in or close to <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10<\/jats:italic> (encoding <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010) in preventing <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>. Homozygous carriers of the variant allele of rs6983267 (ca. 25% of the population) halved their risk for <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> by aspirin use compared to homozygous wildtype carriers who did not benefit from aspirin intake. No interaction between use of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s and <jats:italic><jats:styled-content style=\"fixed-case\">PTGS<\/jats:styled-content>\u20102<\/jats:italic> (encoding <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102) in relation to <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> risk was detected. Other findings of interactions between genes in inflammatory and oncogenic pathways and <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s were considered suggestive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Knowledge of underlying biological effects of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s in relation to <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> is scarce and the basis for stratifying the patients for preventive treatment is not yet available. Further studies assessing interactions between long\u2010term <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> exposure and genetic variation in relation to <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> are warranted in large well\u2010characterised prospective cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12807","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:35:09Z","timestamp":1401323709000},"page":"147-159","source":"Crossref","is-referenced-by-count":29,"title":["Systematic review: interactions between aspirin, and other nonsteroidal anti\u2010inflammatory drugs, and polymorphisms in relation to colorectal cancer"],"prefix":"10.1111","volume":"40","author":[{"given":"V.","family":"Andersen","sequence":"first","affiliation":[{"name":"Organ Center Hospital of Southern Jutland Aabenraa Denmark"},{"name":"Institute of Regional Health Research University of Southern Denmark Odense Denmark"},{"name":"Medical Department Regional Hospital Viborg Viborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Vogel","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Cancer Research Fund Internationalhttp:\/\/www.wcrf.org\/cancer_statistics\/data_specific_cancers\/index.php 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24343"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-112211-154330"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60747-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0391"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.09.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152312803476255"},{"key":"e_1_2_7_10_1","first-page":"3110","article-title":"Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis","volume":"55","author":"Piazza GA","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3043894"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1593-y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.11.025"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30331-9_6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-407"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-484"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12180"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-183"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.668933"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078366"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2007.04.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/156800908786733414"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060464"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2012.04.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-1319-8"},{"key":"e_1_2_7_27_1","first-page":"140","article-title":"Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia","volume":"4","author":"Abbenhardt C","year":"2013","journal-title":"Int J Mol Epidemiol Genet"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0282-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22042"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs305"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs296"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21885"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21841"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26314"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2240"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2687"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23135"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9049-x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3280d5121c"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.04.021"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-0417-0"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-0411-6"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000174786.85238.63"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0878"},{"key":"e_1_2_7_45_1","first-page":"1305","article-title":"Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia","volume":"11","author":"Lin HJ","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601906"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt331"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283417f76"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22157"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.10.006"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.01.006"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1042\/bse0500265"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1206"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2657-z"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9164-3"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.04.015"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000003"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90246-1"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00010"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0166"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21440"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2012.01.009"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.10.015"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02342.x"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.01.006"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1101::AID-ANR6>3.0.CO;2-Y"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.1.47"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.15.1220"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.38"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61543-7"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12807","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:22:46Z","timestamp":1695572566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/apt.12807"],"URL":"https:\/\/doi.org\/10.1111\/apt.12807","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}