{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:57:51Z","timestamp":1790247471355,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Hospital of Angers"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent longitudinal studies have emphasised the prognostic value of noninvasive tests of liver fibrosis and cross\u2010sectional studies have shown their combination significantly improves diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the prognostic accuracy of six blood fibrosis tests and liver biopsy, and evaluate if test combination improves the liver\u2010prognosis assessment in chronic hepatitis C (CHC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 373 patients with compensated CHC, liver biopsy (Metavir F) and blood tests targeting fibrosis (APRI, FIB4, Fibrotest, Hepascore, FibroMeter) or cirrhosis (CirrhoMeter) were included. Significant liver\u2010related events (SLRE) and liver\u2010related deaths were recorded during follow\u2010up (started the day of biopsy).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the median follow\u2010up of 9.5\u00a0years (3508 person\u2010years), 47 patients had a SLRE and 23 patients died from liver\u2010related causes. For the prediction of first SLRE, most blood tests allowed higher prognostication than Metavir F [Harrell C\u2010index: 0.811 (95% CI: 0.751\u20130.868)] with a significant increase for FIB4: 0.879 [0.832\u20130.919] (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.002), FibroMeter: 0.870 [0.812\u20130.922] (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005) and APRI: 0.861 [0.813\u20130.902] (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.039). Multivariate analysis identified FibroMeter, CirrhoMeter and sustained viral response as independent predictors of first SLRE. CirrhoMeter was the only independent predictor of liver\u2010related death. The combination of FibroMeter and CirrhoMeter classifications into a new FM\/CM classification improved the liver\u2010prognosis assessment compared to Metavir F staging or single tests by identifying five subgroups of patients with significantly different prognoses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Some blood fibrosis tests are more accurate than liver biopsy for determining liver prognosis in CHC. A new combination of two complementary blood tests, one targeted for fibrosis and the other for cirrhosis, optimises assessment of liver\u2010prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12813","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T21:38:04Z","timestamp":1401745084000},"page":"178-188","source":"Crossref","is-referenced-by-count":38,"title":["Combination of blood tests for significant fibrosis and cirrhosis improves the assessment of liver\u2010prognosis in chronic hepatitis C"],"prefix":"10.1111","volume":"40","author":[{"given":"J.","family":"Boursier","sequence":"first","affiliation":[{"name":"Liver\u2010Gastroenterology Department University Hospital Angers France"},{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brochard","sequence":"additional","affiliation":[{"name":"Liver\u2010Gastroenterology Department University Hospital Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bertrais","sequence":"additional","affiliation":[{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Michalak","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Gallois","sequence":"additional","affiliation":[{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"},{"name":"Biochemistry Department University Hospital Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fouchard\u2010Hubert","sequence":"additional","affiliation":[{"name":"Liver\u2010Gastroenterology Department University Hospital Angers France"},{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Oberti","sequence":"additional","affiliation":[{"name":"Liver\u2010Gastroenterology Department University Hospital Angers France"},{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010C.","family":"Rousselet","sequence":"additional","affiliation":[{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"},{"name":"Pathology Department University Hospital Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cal\u00e8s","sequence":"additional","affiliation":[{"name":"Liver\u2010Gastroenterology Department University Hospital Angers France"},{"name":"HIFIH Laboratory UPRES 3859, SFR 4208 LUNAM University Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.08.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22759"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22517"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22576"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.203166"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.070961"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.746"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21363"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22859"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01789.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_7_17_1","first-page":"329A","article-title":"Clinical stages of cirrhosis: a multicenter cohort study of 1858 patients","volume":"52","author":"D'Amico G","year":"2010","journal-title":"Hepatology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.048389"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.06.020"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32830cebd7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-132"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-3-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1741826710389354"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12327"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22375"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23315"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026783"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-013-2705-y"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22870"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25616"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.058"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12813","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:22:10Z","timestamp":1695558130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/apt.12813"],"URL":"https:\/\/doi.org\/10.1111\/apt.12813","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718431486.793495955","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,2]]}}}