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Non cardia gastric cancer is a disease that has declined in global incidence but has remained as an extremely lethal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review recent advances in epidemiology and strategies in prevention of non cardia gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A rapid literature search strategy was developed for all English language literature published before March 2013. The search was conducted using the electronic databases PubMed and <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>. The search strategy included the keywords \u2018stomach neoplasms\u2019, \u2018gastric cancer\u2019, \u2018epidemiology\u2019, \u2018risk factor\u2019, \u2018early detection of cancer\u2019, \u2018mass screening\u2019, \u2018cancer burden\u2019, \u2018prevention\u2019 and \u2018cost\u2010effectiveness\u2019. The search strategy was adjusted according to different requirements for each database. The specific search was also performed in cancer\u2010related websites for country\u2010specific information. The search was limited to past 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gastric cancer is the fifth most common cancer but the third leading cause of cancer death. The case fatality rate is 75%. Screening by radiological or endoscopic methods has limited success in prevention of gastric cancer. <jats:italic>Helicobacter pylori<\/jats:italic> has been identified as a carcinogen, accounting for 60\u201370% of gastric cancer globally and eradication is a potential preventive measure. A meta\u2010analysis in 2009 demonstrated that individuals treated with <jats:italic>H. pylori<\/jats:italic> eradication therapy can reduce gastric cancer risk. The extended Shandong Intervention trial that lasted 14.3\u00a0years showed that <jats:italic>H. pylori<\/jats:italic> eradication therapy significantly reduced gastric cancer incidence by 39%. Consensus groups from Asia, Europe and Japan have recommended <jats:italic>H. pylori<\/jats:italic> eradication as primary prevention in high\u2010risk areas. Following eradication therapy, endoscopic surveillance of pre\u2010malignant lesions using enhanced imaging appears to be another promising preventive strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric cancer remains a major diagnostic and therapeutic challenge. There is emerging evidence that <jats:italic>H. pylori<\/jats:italic> eradication in high gastric cancer regions can lead to a decline in the incidence of this highly lethal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12814","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T07:20:11Z","timestamp":1402384811000},"page":"250-260","source":"Crossref","is-referenced-by-count":337,"title":["Review article: the epidemiology and prevention of gastric cancer"],"prefix":"10.1111","volume":"40","author":[{"given":"K. M.","family":"Fock","sequence":"first","affiliation":[{"name":"Changi General Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Globocan2008. Available at:globocan.iarc.fr\/factsheets\/cancers\/stomach.asp. Accessed September 5 2012."},{"key":"e_1_2_5_3_1","unstructured":"Globocan2012. 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