{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:34:11Z","timestamp":1791988451767,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aprepitant (Emend, Merck Sharp &amp; Dohme Ltd, Haarlem, the Netherlands), a neurokinin\u20101 receptor antagonist, prevents vomiting in a range of conditions. No data are available on its use in children with cyclical vomiting syndrome (<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the efficacy of aprepitant as prophylactic treatment or acute intervention in<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>children refractory to conventional therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one children (median age: 8\u00a0years) fulfilling<jats:styled-content style=\"fixed-case\">NASPGHAN<\/jats:styled-content>criteria treated acutely (RegA) or prophylactically (RegP) with aprepitant were retrospectively reviewed. Primary outcome was the clinical response (decrease in frequency and intensity of<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>episodes). Secondary outcomes were: number of<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>episodes\/year, number of hospital admissions\/year,<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>episode duration, number of vomits\/h, symptom\u2010free interval length (days), and school attendance percentage. The follow\u2010up period was 18\u201360\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen children received RegP and 25 RegA. One child on RegP stopped treatment due to severe migraine. At 12\u2010months on intention\u2010to\u2010treat analysis, 13 children on RegP (81%) achieved either complete (3\/16, 19%) or partial (10\/16, 62%) clinical response. On RegA, 19 children (76%) had either complete (3\/25, 12%) or partial (16\/25, 64%) response (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.8 vs. RegP). In both RegP and RegA, there was a significant decrease in<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>episodes\/year, hospital admission number\/year,<jats:styled-content style=\"fixed-case\">CVS<\/jats:styled-content>episode length, number of vomits\/h, as well as an increase in symptom\u2010free interval duration and school attendance percentage. Side effects were reported only in RegP (5\/16, 31%) including hiccough (3\/16, 19%), asthenia\/fatigue (2\/16, 12.5%), increased appetite (2\/16, 12.5%), mild headache (1\/16, 6%) and severe migraine (1\/16, 6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aprepitant appears effective for both acute and prophylactic management of paediatric cyclical vomiting syndrome refractory to conventional therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12822","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T04:23:06Z","timestamp":1401942186000},"page":"309-317","source":"Crossref","is-referenced-by-count":89,"title":["Efficacy of the neurokinin\u20101 receptor antagonist aprepitant in children with cyclical vomiting syndrome"],"prefix":"10.1111","volume":"40","author":[{"given":"F.","family":"Cristofori","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Thapar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Saliakellis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kumaraguru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elawad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kiparissi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"K\u00f6glmeier","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Great Ormond Street Hospital Institute of Child Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Biomedical Science St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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