{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:20Z","timestamp":1790517380374,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Psychology Department, Macquarie University","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Activation of the immune system has been demonstrated in atopy and functional gastrointestinal disorders (FGIDs). Previous data from our group have suggested a connection between immune dysregulation, FGIDs and mood disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate if these data translate to clinical practice and examine connections from the perspective of FGIDs to determine whether atopy and FGIDs are connected via mood disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Evidence of irritable bowel syndrome (IBS), functional dyspepsia (FD) and constipation was sought from the medical records of 30\u00a0000 primary care records over a minimum 5 year period. The same records yielded diagnoses of four atopic conditions (asthma, eczema, allergic rhinitis\/hay fever and conjunctivitis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Atopic conditions were found in excess among all FGID groups considered when compared with controls. In the groups with IBS alone (OR\u00a0=\u00a01.43, 1.29\u20131.58), FD alone (OR\u00a0=\u00a01.41, 1.26\u20131.58) and those with multiple FGIDs (OR\u00a0=\u00a01.92, 1.75\u20132.12) there was elevated prevalence of asthma compared with controls without a FGID. Across disorders the excess was generally highest among patients diagnosed with multiple FGIDs (rhinitis\/hay fever OR\u00a0=\u00a03.74, 3.32\u20134.20; conjunctivitis OR\u00a0=\u00a03.00, 2.49\u20133.62) and was only partly explained by a common association between both FGIDs and atopic conditions with mood disorders, although not for every atopic\/FGID combination (rhinitis\/hay fever OR\u00a0=\u00a02.60, 2.29\u20132.96, conjunctivitis OR\u00a0=\u00a02.34, 1.90\u20132.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Irritable bowel syndrome, functional dyspepsia and constipation share an association with atopy that is only partly explained via a common connection with mood disorders. These data have important implications for understanding both the pathophysiology of functional gastrointestinal disorders and development of new treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12846","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T07:22:44Z","timestamp":1403680964000},"page":"382-391","source":"Crossref","is-referenced-by-count":107,"title":["The overlap of atopy and functional gastrointestinal disorders among 23\u00a0471 patients in primary care"],"prefix":"10.1111","volume":"40","author":[{"given":"M. P.","family":"Jones","sequence":"first","affiliation":[{"name":"Psychology Department Macquarie University North Ryde NSW USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Walker","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Callaghan NSW USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Ford","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital Leeds UK"},{"name":"Leeds Institute of Biomedical and Clinical Sciences Leeds University Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Talley","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle Callaghan NSW USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441207"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1222610"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010113231505"},{"key":"e_1_2_7_5_1","first-page":"977","article-title":"Expression of interleukin\u20104 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic","volume":"117","author":"Chan LS","year":"2001","journal-title":"Dermatitis"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2014.881716"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.6.743"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03937.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0379-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04282.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01220.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.049585"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9530-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.666"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.58958"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.696681"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02727.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6405.1593"},{"key":"e_1_2_7_19_1","first-page":"468","article-title":"The role of cow's milk allergy in pediatric chronic constipation: a randomized clinical trial","volume":"22","author":"Dehghani SM","year":"2012","journal-title":"Iran J Pediatr"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300474"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.131"},{"key":"e_1_2_7_22_1","first-page":"251","article-title":"Generalisability of The Health Improvement Network (THIN) database: demographics, chronic disease prevalence and mortality rates","volume":"19","author":"Blak BT","year":"2011","journal-title":"Inform Prim Care"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1335"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03537.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6732.1092"},{"key":"e_1_2_7_26_1","volume-title":"British National Formulary","author":"Britain JFCotBMAaTPSoG","year":"2013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01484.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.15"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07027.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409090447"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01303162"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06244.x"},{"key":"e_1_2_7_34_1","first-page":"1026","article-title":"Upper gastrointestinal symptoms and asthma: a manifestation of allergy?","volume":"57","author":"Powell N","year":"2008","journal-title":"Gut"},{"issue":"8","key":"e_1_2_7_35_1","first-page":"38","article-title":"Irritable bowel syndrome, anxiety, and depression: what are the links?","volume":"62","author":"Lydiard RB","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2741\/s44"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i25.3456"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01749.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.015"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0197-5"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62202-8"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00049"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01299.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.043"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.14618"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.07.170"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.046"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12184"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60404-8"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12846","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T11:14:01Z","timestamp":1696504441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/apt.12846"],"URL":"https:\/\/doi.org\/10.1111\/apt.12846","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,25]]}}}