{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T05:12:10Z","timestamp":1791695530963,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T00:00:00Z","timestamp":1404950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK56033"],"award-info":[{"award-number":["DK56033"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK092217"],"award-info":[{"award-number":["DK092217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Reckitt Benckiser Gropu plc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent studies have shown that Gaviscon Double Action Liquid (a combination alginate\u2010antacid) administered post\u2010prandially co\u2010localises with the acid pocket, the \u2018reservoir\u2019 for post\u2010prandial acid reflux.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To compare the effectiveness of Gaviscon Double Action Liquid to an equivalent strength antacid without alginate in controlling post\u2010prandial acid reflux in\n                      <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fourteen GERD patients undertook two 3.5\u2010h high\u2010resolution manometry\/\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      \u2010impedance studies during which they ate a standardised meal. In a double\u2010blinded randomised crossover design they then took Gaviscon or CVS brand antacid, each with ~18\u00a0mmol\/L acid neutralising capacity. The primary outcome was distal oesophageal acid exposure; secondary outcomes were number of reflux events, proximal extent of reflux, nadir\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      of the refluxate, mechanism of reflux and reflux symptoms scored with a validated instrument.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten patients completed the study. Gaviscon studies had significantly less distal oesophageal acid exposure and greater nadir refluxate\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      in the 30\u2013150\u00a0min post\u2010prandial period than antacid studies. There were no differences in the number of reflux events (acid or weakly acidic) or the number of proximal reflux events (15\u201317\u00a0cm above the LES) with either study medication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gaviscon Double Action Liquid is more effective than an antacid without alginate in controlling post\u2010prandial oesophageal acid exposure. However, the number and spatial distribution of reflux events within the oesophagus are similar. This suggests that Gaviscon main effectiveness relates to its co\u2010localisation with and displacement\/neutralisation of the post\u2010prandial acid pocket, rather than preventing reflux.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.12857","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T03:46:38Z","timestamp":1404963998000},"page":"531-537","source":"Crossref","is-referenced-by-count":91,"title":["Gaviscon Double Action Liquid (antacid &amp; alginate) is more effective than antacid in controlling post\u2010prandial oesophageal acid exposure in\n                    <scp>GERD<\/scp>\n                    patients: a double\u2010blind crossover study"],"prefix":"10.1111","volume":"40","author":[{"given":"A.","family":"De Ruigh","sequence":"first","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"},{"name":"Department of Gastroenterology Academic Medical Center Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Roman","sequence":"additional","affiliation":[{"name":"Digestive Physiology Hospices Civils de Lyon Lyon I University Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"},{"name":"Division of Gastroenterology Department of Internal Medicine University of Michigan Health Systems Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Kahrilas","sequence":"additional","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00153-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27997"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.132"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.161927"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.178061"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01488.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.045"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02489.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00444.2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04728.x"},{"key":"e_1_2_7_14_1","first-page":"59","article-title":"The movements of the stomach, studied by means of the Rontgen Rays","volume":"2","author":"Cannon WB","year":"1898","journal-title":"Boston Soc Med Sci"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04678.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12318"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.01.036"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02298.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12640"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20191"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12857","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:13:09Z","timestamp":1696338789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,10]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/apt.12857"],"URL":"https:\/\/doi.org\/10.1111\/apt.12857","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,10]]}}}