{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:59:23Z","timestamp":1784829563641,"version":"3.55.0"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T00:00:00Z","timestamp":1404432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between eosinophilic oesophagitis (EoE) and coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) remains controversial, with studies yielding varied results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To systematically review the evidence of a possible association between both diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic searches were performed with keywords relating to EoE and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCOPUS<\/jats:styled-content> databases. Summary estimates were calculated. A random\u2010effects model was used depending on heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>). Publication bias was assessed with the aid of funnel plot analysis, along with the Begg\u2013Mazumdar, Harbord and Egger tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search yielded 197 references; 30 were included in the quantitative summary, with most of these presenting methodological inconsistencies. Significant publication bias in favour of short studies reporting positive associations between both diseases was documented. The prevalence of EoE in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> ranged from 0% to 10.7% (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a078.9%). Prevalence of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> in EoE varied between 0.16% and 57.1% (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a089%). One high\u2010quality, prospective, randomly selected, population\u2010based study documented a 1.1% prevalence of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, with no patients presenting EoE. Clinical and methodological heterogeneity hindered the performance of quantitative summaries for prevalence data. A gluten\u2010free diet was effective in achieving histological remission of EoE in 32.1% of coeliac patients (95% confidence interval, 14.9\u201352.2%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a052.2%), which was similar to that expected for wheat elimination in EoE patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While a lack of valid studies prevents us from completely ruling out a true association between EoE and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, currently available evidence does not support this hypothesis. Indeed, the only epidemiological study with sufficient validity points to the independence of both diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12859","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T01:19:28Z","timestamp":1404523168000},"page":"422-434","source":"Crossref","is-referenced-by-count":47,"title":["Systematic review: the association between eosinophilic oesophagitis and coeliac disease"],"prefix":"10.1111","volume":"40","author":[{"given":"A. J.","family":"Lucendo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital General de Tomelloso Tomelloso Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Arias","sequence":"additional","affiliation":[{"name":"Research Unit Complejo Hospitalario La Mancha Centro Alc\u00e1zar de San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Tenias","sequence":"additional","affiliation":[{"name":"Research Unit Complejo Hospitalario La Mancha Centro Alc\u00e1zar de San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119917"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90637-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.02.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1113994"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2012.07.008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)93155-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80354-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.03.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3402\/ijch.v72i0.21403"},{"key":"e_1_2_7_14_1","first-page":"268","article-title":"Coeliac disease in the 21st century: no longer \u201ckids' stuff\u201d","volume":"4","author":"Lucendo AJ","year":"2011","journal-title":"Gastroenterol Res"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03502.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.030"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.09.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835a4c95"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.12.68"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02787.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i32.4335"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200610000-00062"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000243430.32087.5c"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03388.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.117986"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318221aefd"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(08)61346-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.792389"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.008"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2014.909727"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2010.01.015"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_7_34_1","first-page":"251","article-title":"Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP, STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"82","author":"Elm E","year":"2008","journal-title":"Rev Esp Salud Publica"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2380"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05239.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/MPG.0b013e3181a70af4","article-title":"Celiac disease and eosinophilic esophagitis: a true association","volume":"50","author":"Leslie C","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_7_41_1","first-page":"73","article-title":"Eosinophilic esophagitis, celiac disease, and immunoglobulin E\u2010mediated allergy in a 2\u2010year\u2010old child","volume":"21","author":"S\u00e1nchez\u2010Garc\u00eda S","year":"2011","journal-title":"J Invest Allergol Clin Immunol"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/159257"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-96"},{"key":"e_1_2_7_44_1","first-page":"43","article-title":"Eosinophilic esophagitis and allergy in children","volume":"20","author":"Hoz B","year":"2009","journal-title":"Pediatr Allergy Immunol"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(09)60521-1"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(10)60806-2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(10)60547-6"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(10)60795-0"},{"key":"e_1_2_7_49_1","first-page":"E13","article-title":"Importance of pan\u2010biopsy of the upper gastrointestinal tract in celiac disease","volume":"51","author":"Weinstein T","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_7_50_1","first-page":"E15","article-title":"Pediatric eosinophilic esophagitis: the northern virginia experience","volume":"51","author":"Hiremath G","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_7_51_1","first-page":"143","article-title":"Underlying diseases and other gastrointestinal abnormalities in patients with Celiac disease","volume":"13","author":"Patel C","year":"2010","journal-title":"Pediatr Dev Pathol"},{"key":"e_1_2_7_52_1","first-page":"A105","article-title":"Occurrence of eosinophilic esophagitis in patients with Celiac Disease","volume":"105","author":"Garrett JP","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.186338.80"},{"key":"e_1_2_7_54_1","first-page":"196","article-title":"Prevalence of eosinophilic esophagitis in pediatric population: single\u2010center experience in northwestern India","volume":"26","author":"Prasad KK","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.859"},{"key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1016\/S0016-5085(11)60977-3","article-title":"Low prevalence of extraesophageal histopathology in eosinophilic esophagitis (EoE) in adults","volume":"140","author":"Ho N","year":"2011","journal-title":"Gastroenterology"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302724.0722"},{"issue":"1","key":"e_1_2_7_58_1","doi-asserted-by":"crossref","first-page":"S517","DOI":"10.14309\/00000434-201210001-01303","article-title":"Simultaneous onset of eosinophilic esophagitis (EoE) and celiac sprue (CS) in an adult with response to gluten\u2010free diet","volume":"107","author":"Costable J","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a1cda3"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.1310"},{"key":"e_1_2_7_61_1","doi-asserted-by":"crossref","first-page":"S288","DOI":"10.14309\/00000434-201310001-00967","article-title":"nullHard to swallownull: dysphagia due to eosinophilic esophagitis in adult patient with celiac disease","volume":"108","author":"Alli\u2010Akintade L","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_62_1","doi-asserted-by":"crossref","first-page":"S620","DOI":"10.1038\/ajg.2013.272","article-title":"Eosinophilic Esophagitis Associated with Celiac Disease in Children","volume":"108","author":"Dharmaraj R","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1383-2"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0311-2"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06028.x"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750024362"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1627"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.107714"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.06.023"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821cf503"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.664"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.12.034"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.1.345"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-5-200709040-00003"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12859","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:13:48Z","timestamp":1696353228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,4]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/apt.12859"],"URL":"https:\/\/doi.org\/10.1111\/apt.12859","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,4]]}}}