{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:17:29Z","timestamp":1780319849327,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T00:00:00Z","timestamp":1405209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"TAP Pharmaceutical Products Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ilaprazole, a proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) currently in clinical use, may provide improved acid suppression vs. other <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the pharmacodynamic and pharmacokinetic profiles of ilaprazole and esomeprazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A phase 1, randomised, open\u2010label, single\u2010centre, 4\u2010period crossover study was conducted in 40 healthy volunteers. Ilaprazole 10, 20 or 40\u00a0mg or esomeprazole 40\u00a0mg was administered once daily for 5\u00a0days with \u22655\u2010day washout intervals. Pharmacokinetic blood samples and intragastric pH measurements were collected at scheduled timepoints for 24\u00a0h after dosing on Days 1 and 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Esomeprazole 40\u00a0mg provided significantly better pH control during the initial hours (0\u20134\u00a0h) after a single dose, but ilaprazole (particularly 20 and 40\u00a0mg) provided significantly better pH control for the entire 24\u2010h period and during evening and overnight hours after single and multiple doses. Increasing ilaprazole doses resulted in dose\u2010proportional increases in peak plasma concentration and area under the plasma concentration vs. time curve following single and multiple doses. Ilaprazole was safe and generally well tolerated; an unexpectedly high incidence of allergic eye and skin reactions were observed but were not specific to any dosing regimen. Plasma gastrin concentrations did not increase proportionately with increasing ilaprazole dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ilaprazole provided significantly better pH control over 24\u00a0h and during evening and overnight hours compared with esomeprazole in healthy volunteers, which may translate to greater relief of night\u2010time heartburn in the clinical setting for patients with gastric acid\u2010related disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12860","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T16:25:52Z","timestamp":1405441552000},"page":"548-561","source":"Crossref","is-referenced-by-count":35,"title":["The pharmacokinetics, pharmacodynamics and safety of oral doses of ilaprazole 10, 20 and 40\u00a0mg and esomeprazole 40\u00a0mg in healthy subjects: a randomised, open\u2010label crossover study"],"prefix":"10.1111","volume":"40","author":[{"given":"J. S.","family":"Shin","sequence":"first","affiliation":[{"name":"Central Research Institute IL\u2010YANG Pharmaceutical Co., Ltd. Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Central Research Institute IL\u2010YANG Pharmaceutical Co., Ltd. Yongin South Korea"},{"name":"Department of Chemistry Graduate School Kyung Hee University Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Cho","sequence":"additional","affiliation":[{"name":"Central Research Institute IL\u2010YANG Pharmaceutical Co., Ltd. Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. L.","family":"Park","sequence":"additional","affiliation":[{"name":"Central Research Institute IL\u2010YANG Pharmaceutical Co., Ltd. Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kukulka","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. Deerfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010T.","family":"Wu","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas, Inc. Deerfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Central Research Institute IL\u2010YANG Pharmaceutical Co., Ltd. Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010H.","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200501000-00021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.45"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"e_1_2_7_5_1","first-page":"273","article-title":"Proton pump inhibitors: an update","volume":"66","author":"Vanderhoff BT","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00557.x"},{"key":"e_1_2_7_7_1","first-page":"204","article-title":"Effects of IY\u201081149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo","volume":"51","author":"Kwon D","year":"2001","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.109155"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181e88515"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.639353"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0072-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2011.622416"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270011408611"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04219.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41956.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02943.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03196.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01893.x"},{"issue":"1","key":"e_1_2_7_19_1","first-page":"S35","article-title":"Improving on PPI\u2010based therapy of GORD","volume":"13","author":"Sachs G","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12860","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:12:54Z","timestamp":1696353174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,13]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/apt.12860"],"URL":"https:\/\/doi.org\/10.1111\/apt.12860","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,13]]}}}