{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:06:36Z","timestamp":1777111596271,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Type 2 diabetes is known to negatively impact the outcome of chronic liver disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the impact of diabetes on the outcomes of liver transplants (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study cohort included adults (&gt;18\u00a0years) who received <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> in the US between 1994 and 2013 (The Scientific Registry of Transplant Recipients). Pre\u2010 and post\u2010transplant diabetes was recorded in patients with mortality follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 85\u00a0194 liver transplant recipients. Of those, 11.2% had history of pre\u2010transplant diabetes. The most common indications for liver transplant were hepatitis C (36.4%), alcohol\u2010related liver disease (20.6%), primary liver malignancy of unspecified aetiology (14.7%), cryptogenic cirrhosis (8.0%), hepatitis B (4.6%) and non\u2010alcoholic steatohepatitis (3.9%). A total of 96.5% transplants were from deceased donors, and 7.9% donors had history of diabetes. During an average 6.5\u00a0years of follow\u2010up, 31.3% recipients died and 8.8% had a graft failure. In multivariate survival analysis [at least 5\u00a0years of cohort follow\u2010up (<jats:italic>N<\/jats:italic>\u00a0=\u00a035\u00a0870)], after adjustment for age, ethnicity, insurance type, history of chronic diseases, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection and noncompliance, independent predictors of recipient mortality included the presence of pre\u2010transplant diabetes [adjusted hazard ratio (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a0=\u00a01.21 (1.12\u20131.30)] and developing diabetes post\u2010transplant [1.06 (1.02\u20131.11)]. Donor's history of diabetes was also independently associated with higher mortality [1.10 (1.02\u20131.19)]. Furthermore, donor's history of diabetes was also associated with an increased the risk of liver graft failure [1.35 (1.24\u20131.47)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Presence of type 2 diabetes pre\u2010 and post\u2010transplant, as well as presence of type 2 diabetes in the donors, are all associated with an increased risk of adverse post\u2010transplant outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12881","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:25:02Z","timestamp":1405556702000},"page":"686-694","source":"Crossref","is-referenced-by-count":75,"title":["The impact of type 2 diabetes and obesity on the long\u2010term outcomes of more than 85\u00a0000 liver transplant recipients in the US"],"prefix":"10.1111","volume":"40","author":[{"given":"Z. M.","family":"Younossi","sequence":"first","affiliation":[{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stepanova","sequence":"additional","affiliation":[{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Saab","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at the University of California at Los Angeles Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kalwaney","sequence":"additional","affiliation":[{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Clement","sequence":"additional","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Henry","sequence":"additional","affiliation":[{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a15db4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0070"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.05.072"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.040"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.213553"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1267-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199611150-00011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283457d5d"},{"key":"e_1_2_7_11_1","unstructured":"2009 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1999\u20132008. 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