{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:17:05Z","timestamp":1791587825141,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sapienza university Roma","award":["000323"],"award-info":[{"award-number":["000323"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adequate gluten\u2010free diet (<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>) is the only treatment for coeliac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>). However, no agreement has been reached on either how and when to assess patient adherence to<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>or its effectiveness on villous atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess, in a prospective study, patient adherence to and efficacy of<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>on histological recovery after 1\u2010year of<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2009 and 2012, we enrolled 65 consecutive newly\u2010diagnosed adult patients (median age 38\u00a0years, 18\u201370) with biopsy\u2010proven atrophic<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Patients were re\u2010evaluated after 1 year of<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>with duodenal histology, serological assays, symptoms and a dietary interview based on a validated questionnaire. Complete histological recovery was defined as the absence of villous atrophy and \u226430\/100 intraepithelial lymphocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 81.5% of patients had adequate adherence (<jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>) to<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>, whereas 18.5% had an inadequate adherence (<jats:styled-content style=\"fixed-case\">IADA<\/jats:styled-content>); 66% of<jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>patients and no<jats:styled-content style=\"fixed-case\">IADA<\/jats:styled-content>patients achieved complete histological recovery (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.00001). Among<jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>patients, antibody seroconversion and symptoms were not significantly different between patients who achieved complete histological recovery and those who achieved partial histological recovery with<jats:italic>P\u00a0<\/jats:italic>=\u00a00.309 and<jats:italic>P\u00a0<\/jats:italic>=\u00a00.197, respectively. Multivariate analysis showed that Marsh 3C was a risk factor for incomplete histological recovery in<jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>patients (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>8.74, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.87\u201340.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows that complete histological recovery after 1\u2010year of<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>in adult patients, who are assessed as adherent to the<jats:styled-content style=\"fixed-case\">GFD<\/jats:styled-content>, can be obtained in 66% of patients. Patients with severe histological damage at diagnosis are at risk for incomplete histological recovery 1\u00a0year later.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12893","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T07:42:19Z","timestamp":1406533339000},"page":"639-647","source":"Crossref","is-referenced-by-count":64,"title":["Histological recovery and gluten\u2010free diet adherence: a prospective 1\u2010year follow\u2010up study of adult patients with coeliac disease"],"prefix":"10.1111","volume":"40","author":[{"given":"G.","family":"Galli","sequence":"first","affiliation":[{"name":"Department of Digestive and Liver Disease Sant'Andrea Hospital Sapienza University Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Digestive and Liver Disease Sant'Andrea Hospital Sapienza University Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Digestive and Liver Disease Sant'Andrea Hospital Sapienza University Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pilozzi","sequence":"additional","affiliation":[{"name":"Department of Pathology Sant'Andrea Hospital Sapienza University Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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