{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:54:35Z","timestamp":1790394875679,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n The natural history of nonfistulising perianal Crohn's disease (\n PCD<\/jats:styled-content>\n ) remains unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To assess the long\u2010term outcome of anorectal strictures.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n All outcomes of\n PCD<\/jats:styled-content>\n patients with anorectal stricture followed in a single unit from 2005 to 2013 were reviewed, as well as subsequent therapeutic management. Cumulative incidence of stricture healing (disappearance of the anal stricture) was estimated using a Kaplan\u2013Meier method and factor associated with an unfavourable course (persistent stricture S2, persistent stoma or proctectomy) with nonparametric test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 102 patients (M\/F: 37\/65) were included. The duration of\n CD<\/jats:styled-content>\n at diagnosis was 8.9\u00a0years. After a median follow\u2010up period of 2.8\u00a0years, 52 of the 88 followed patients (59%) achieved anorectal stricture healing. Two patients (2%) developed anal adenocarcinoma. Female gender [\n HR<\/jats:styled-content>\n 2.05 (1.1\u20134.03),\n P<\/jats:italic>\n \u00a0=\u00a00.0221], disease duration of\n CD<\/jats:styled-content>\n of less than 10\u00a0years [\n HR<\/jats:styled-content>\n 1.94 (1.01\u20133.63),\n P<\/jats:italic>\n \u00a0=\u00a00.0271], and anal fistula at stricture diagnosis [\n HR<\/jats:styled-content>\n 2.36 (1.21\u20135.05),\n P<\/jats:italic>\n \u00a0=\u00a00.0106) were significantly associated with anorectal stricture healing in a multivariate analysis model. Twenty\u2010eight patients (32%) had an unfavourable course at the end of follow\u2010up. Gender and introduction or optimisation of\n TNF<\/jats:styled-content>\n \u03b1 antagonist treatment decreased the risk of unfavourable course in multivariate analysis. Conversely, the Luminal B2 phenotype at\n CD<\/jats:styled-content>\n diagnosis was the only factor associated with unfavourable course.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Anorectal stricture does not imply a nonreversible and complicated condition related to severe perianal Crohn's disease. However, both the diagnosis of cancer and sepsis drainage remain challenging in this situation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12894","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T09:01:22Z","timestamp":1407747682000},"page":"796-803","source":"Crossref","is-referenced-by-count":51,"title":["Anorectal stricture in 102 patients with Crohn's disease: natural history in the era of biologics"],"prefix":"10.1111","volume":"40","author":[{"given":"C.","family":"Brochard","sequence":"first","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Services d'Explorations Fonctionnelles Digestives CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Siproudhis","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wallenhorst","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cuen","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. N.","family":"d'Halluin","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garros","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010F.","family":"Bretagne","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bouguen","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.6.6.515"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02060.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.042"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21261"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20264"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02253493"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000161030.25860.c1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750711"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.3780060103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92767-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199501000-00008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236639"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04710.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010306709"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2013.08.002"}],"container-title":["Alimentary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.12894","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:13:02Z","timestamp":1695481982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.12894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/apt.12894"],"URL":"https:\/\/doi.org\/10.1111\/apt.12894","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}