{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:48:59Z","timestamp":1792435739054,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pathophysiological mechanisms associated with neoplastic progression in patients with short\u2010segment Barrett's oesophagus (<jats:styled-content style=\"fixed-case\">SSBO<\/jats:styled-content>), who represent the vast majority of the Barrett population, have not been defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate pathophysiological characteristics of patients with <jats:styled-content style=\"fixed-case\">SSBO<\/jats:styled-content> and dysplasia detected at 3\u2010year surveillance endoscopy (incident dysplasia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SSBO underwent impedance\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> monitoring during heartburn\u2010suppressing PPI therapy. Fifteen patients (12 males, median age 62\u00a0years) with incident dysplasia and 50 patients (43 males, median age 59\u00a0years) without dysplasia were compared. Impedance\u2010<jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> parameters, including chemical clearance assessed by the post\u2010reflux swallow\u2010induced peristaltic wave (PSPW) index, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients declared persisting heartburn suppression on maintenance <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy at 3\u2010year follow\u2010up, 58\/65 (89%) with standard dosages. The median gastric and oesophageal acid exposure time (<jats:styled-content style=\"fixed-case\">GAET<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OAET<\/jats:styled-content>) did not differ between patients with and without incident dysplasia at the time of surveillance (36% and 0.6% vs. 33% and 0.5%) or index endoscopy (33% and 0.3% vs. 41% and 0.5%) (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05). Contrastingly, the median <jats:styled-content style=\"fixed-case\">PSPW<\/jats:styled-content> index was significantly lower in patients with than in patients without incident dysplasia at the time of surveillance (15%, vs. 32%) and index endoscopy (12% vs. 30%) (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001). The <jats:styled-content style=\"fixed-case\">PSPW<\/jats:styled-content> index, the <jats:styled-content style=\"fixed-case\">GAET<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">OAET<\/jats:styled-content> did not vary over time (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). A <jats:styled-content style=\"fixed-case\">PSPW<\/jats:styled-content> index &lt;26% was predictive of incident dysplasia with a 75% accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neoplastic progression in <jats:styled-content style=\"fixed-case\">SSBO<\/jats:styled-content> is associated with impairment of chemical clearance, but not inadequate acid suppression by <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy. Neoplastic progression in <jats:styled-content style=\"fixed-case\">SSBO<\/jats:styled-content> can be predicted by a low <jats:styled-content style=\"fixed-case\">PSPW<\/jats:styled-content> index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12895","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T09:36:28Z","timestamp":1407144988000},"page":"835-842","source":"Crossref","is-referenced-by-count":25,"title":["Neoplastic progression in short\u2010segment Barrett's oesophagus is associated with impairment of chemical clearance, but not inadequate acid suppression by <scp>proton pump inhibitor<\/scp> therapy"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"Frazzoni","sequence":"first","affiliation":[{"name":"Digestive Pathophysiology Unit Baggiovara Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bertani","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Baggiovara Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Conigliaro","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Baggiovara Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Frazzoni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Losi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Modena\u2010Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Melotti","sequence":"additional","affiliation":[{"name":"Department of Surgery Baggiovara Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145177"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02127.x"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Technology review: esophageal impedance monitoring","volume":"101","author":"Bredenoord AG","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04063.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03863.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402023100503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12080"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.032"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.11.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12693"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00661.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01536.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.05.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04172.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.03.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12299"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0689-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.02.020"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.10"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.040"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2511"}],"container-title":["Alimentary Pharmacology &amp; 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