{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:28:12Z","timestamp":1791444492594,"version":"4.3.3"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have evaluated the effects of rabeprazole on low\u2010dose aspirin (<jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content>)\u2010induced gastroduodenal injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To conduct a randomised, double\u2010blind, triple\u2010dummy, active\u2010controlled, multicentre trial, named the PLANETARIUM study, to assess the efficacy, dose\u2013response relationship and safety of rabeprazole for peptic ulcer recurrence in Japanese patients on long\u2010term <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible patients had a history of endoscopically confirmed peptic ulcers and were receiving long\u2010term <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content> (81 or 100\u00a0mg\/day) therapy for cardiovascular or cerebrovascular protection. Subjects were randomly segregated into three groups receiving rabeprazole 10\u00a0mg once daily (standard dose in Japan), rabeprazole 5\u00a0mg once daily, or teprenone (geranylgeranylacetone; mucosal protective agent commercially available in Japan) 50\u00a0mg three times per day as an active control. The primary endpoint was recurrence of peptic ulcers over 24\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 472 randomised subjects, 452 subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a0151, 150, 151, respectively) constituted the full analysis set. The cumulative recurrence rates of peptic ulcers over 24\u00a0weeks in the 10\u2010 and 5\u2010mg rabeprazole groups were 1.4% and 2.8%, respectively, both of which were significantly lower than that in the teprenone group (21.7%). The cumulative occurrence rate of bleeding ulcers over 24\u00a0weeks in the teprenone group was 4.6%, while bleeding ulcers were not observed in the 10\u2010 or 5\u2010mg rabeprazole groups. Rabeprazole was well tolerated at both doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rabeprazole prevents the recurrence of peptic ulcers with no evidence of a major dose\u2013response effect in subjects on low\u2010dose aspirin therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12907","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T13:28:14Z","timestamp":1407331694000},"page":"780-795","source":"Crossref","is-referenced-by-count":36,"title":["Randomised clinical trial: prevention of recurrence of peptic ulcers by rabeprazole in patients taking low\u2010dose aspirin"],"prefix":"10.1111","volume":"40","author":[{"given":"R.","family":"Iwakiri","sequence":"first","affiliation":[{"name":"Department of Internal Medicine &amp; Gastrointestinal Endoscopy Saga Medical School Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Osaka Medical College Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kato","sequence":"additional","affiliation":[{"name":"Hokkaido University Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Shimane University Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Osaka Medical College Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Yamauchi Medical Clinic Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanomura","sequence":"additional","affiliation":[{"name":"Hokusetsu General Hospital Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Nozaki Tokushukai Hospital Daito Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sugisaki","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd. 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