{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:51:03Z","timestamp":1787223063488,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Liver and Gastrointestinal research (SLO)"},{"name":"Merck Sharpe & Dohme"},{"name":"Netherlands Genomics Initiative","award":["050-060-452"],"award-info":[{"award-number":["050-060-452"]}]},{"name":"The VIRGO consortium","award":["FES0908"],"award-info":[{"award-number":["FES0908"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polymorphisms of the <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content><\/jats:italic>\u2010<jats:italic><jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content><\/jats:italic> gene are associated with the natural clearance of the hepatitis B virus in Asian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content><\/jats:italic> polymorphisms with response to peginterferon (<jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>) in Caucasian chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 262 Caucasian chronic hepatitis B patients infected with HBV genotype A or D, treated with PEG\u2010IFN for 1\u00a0year in two randomised controlled trials (HBV 99\u201001 and PARC study). Response was defined as an HBV DNA &lt;2000\u00a0IU\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> at 6\u00a0months post\u2010treatment. Variations at <jats:italic>HLA\u2010DPA1<\/jats:italic> and <jats:italic>HLA\u2010DPB1<\/jats:italic> were genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 262 patients, 58% was HBeAg\u2010positive and HBV genotype A and D was observed in 32% and 68%, respectively. At 6\u00a0months post\u2010treatment, 57 (22%) patients had achieved an HBV DNA &lt;2000\u00a0IU\/mL. <jats:italic>HLA\u2010DPB1<\/jats:italic> was independently associated with virological response [adjusted odds ratio (OR) 1.8, 95% confidence interval (CI):1.1\u20133.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025], and with an undetectable HBV DNA (adjusted OR 2.4 95% CI: 1.2\u20134.7, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) when adjusted for HBeAg status and other known response modifiers. In HBeAg\u2010positive patients, combined HBeAg seroconversion with HBV DNA &lt;2000\u00a0IU\/mL was increasingly observed with each addition of an <jats:italic>HLA\u2010DPB1<\/jats:italic> G\u2010allele (adjusted OR 2.7, 95% CI: 1.2\u20135.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012). Furthermore, <jats:italic>HLA\u2010DPA1<\/jats:italic> and <jats:italic>HLA\u2010DPB1<\/jats:italic> haplotype block GG showed comparable results for virological and combined response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large cohort of Caucasian <jats:styled-content style=\"fixed-case\">chronic hepatitis B<\/jats:styled-content> patients infected with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> genotypes A or D, polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content><\/jats:italic> are independently associated with both virological and serological response to <jats:styled-content style=\"fixed-case\">PEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> therapy at 6\u00a0months post\u2010treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12910","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T13:16:07Z","timestamp":1407762967000},"page":"811-818","source":"Crossref","is-referenced-by-count":23,"title":["Polymorphisms of <i><scp>HLA<\/scp>\u2010<scp>DP<\/scp><\/i> are associated with response to peginterferon in Caucasian patients with chronic hepatitis B"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-1481","authenticated-orcid":false,"given":"W. P.","family":"Brouwer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Sonneveld","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Tabak","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Simon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hepatology Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cakaloglu","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. S.","family":"Akarca","sequence":"additional","affiliation":[{"name":"Ege \u00dcniversitesi Tip Fakultesi Bornova Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Klinikum der Johann Wolfgang Goethe\u2010Universit\u00e4t Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ferenci","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Heathcote","sequence":"additional","affiliation":[{"name":"Toronto Center for Liver Disease Toronto Western and General Hospital University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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