{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:09:39Z","timestamp":1793196579087,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Consejeria Sanidad Politica Social, Gobierno Extremadura"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n The molecular basis and effects of proton pump inhibitor (\n PPI<\/jats:styled-content>\n ) therapy on\n PPI<\/jats:styled-content>\n \u2010responsive oesophageal eosinophilia (\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n ) and eosinophilic oesophagitis (EoE) remain unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To compare symptom\u2010histological and cytokine gene expression in\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n and EoE patients, at baseline and after specific treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In consecutive adult patients with an EoE phenotype (dysphagia\/food impaction, typical endoscopic findings and >\u00a015\u00a0eos\/\n HPF<\/jats:styled-content>\n ), gene expression of eotaxin\u20103,\n IL<\/jats:styled-content>\n \u201013, and\n IL<\/jats:styled-content>\n \u20105 were determined in distal and proximal oesophagus, at baseline and after omeprazole 40\u00a0mg b.d. for 8\u00a0weeks.\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n was defined by clinicohistological response.\n PPI<\/jats:styled-content>\n nonresponders (EoE) were offered treatment with topical steroids.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifty three patients were re\u2010evaluated on\n PPI<\/jats:styled-content>\n therapy. 23 patients (43%) had\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n and 30 patients (57%) had EoE. At baseline, eotaxin\u20103\/\n IL<\/jats:styled-content>\n \u201013\/\n IL<\/jats:styled-content>\n \u20105 gene expression was indistinguishable between EoE and\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n , excepting increased\n IL<\/jats:styled-content>\n \u20105 expression in proximal oesophagus (12.54 vs. 57,\n P<\/jats:italic>\n \u00a0=\u00a00.029).\n PPI<\/jats:styled-content>\n therapy significantly decreased eotaxin\u20103\/\n IL<\/jats:styled-content>\n \u201013 in\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n , at both oesophageal sites (\n P<\/jats:italic>\n \u00a0\u2264\u00a00.008), and\n IL<\/jats:styled-content>\n \u20105 in distal (\n P<\/jats:italic>\n \u00a0=\u00a00.016), but not in proximal oesophagus. Patients with steroid\u2010responsive EoE also showed a significant decrease in eotaxin\u20103\/\n IL<\/jats:styled-content>\n \u20105 expression at both oesophageal sites. In EoE patients, initial\n PPI<\/jats:styled-content>\n trial significantly decreased distal oesophageal eosinophilia (63.78 to 41.79\u00a0eos\/\n HPF<\/jats:styled-content>\n ,\n P<\/jats:italic>\n \u00a0=\u00a00.025) and led to symptom remission in 16%, but did not influence Th2 markers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Baseline cytokine gene expression in\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n was nearly indistinguishable from EoE.\n PPI<\/jats:styled-content>\n therapy significantly downregulated oesophageal eotaxin\u20103\/Th2\u2010cytokine gene expression in\n PPI<\/jats:styled-content>\n \u2010\n REE<\/jats:styled-content>\n , similarly to that seen in steroid\u2010responsive EoE. A subset of EoE patients showed clinicohistological improvement on\n PPI<\/jats:styled-content>\n therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.12914","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T23:45:06Z","timestamp":1407800706000},"page":"955-965","source":"Crossref","is-referenced-by-count":129,"title":["Proton pump inhibitor\u2010responsive oesophageal eosinophilia correlates with downregulation of eotaxin\u20103 and Th2 cytokines overexpression"],"prefix":"10.1111","volume":"40","author":[{"given":"J.","family":"Molina\u2010Infante","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Rivas","sequence":"additional","affiliation":[{"name":"Research Unit and Molecular Biology Laboratory Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hernandez\u2010Alonso","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vinagre\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Mateos\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Due\u00f1as\u2010Sadornil","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Perez\u2010Gallardo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ferrando\u2010Lamana","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Fernandez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ba\u00f1ares","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n CIBEREHD Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Research Unit and Molecular Biology Laboratory Hospital San Pedro de Alcantara Caceres Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.039"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12332"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.06.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.71"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050037"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302250"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00313-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819c4b3e"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0295-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04922.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2012.02.024"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.024"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301817"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.363"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12636"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01179.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318299f181"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40978.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.469"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03237.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","unstructured":"vanRhjinBD WeijenborgPW VerheijJ et\u00a0al.Proton pump inhibitors partially restore mucosal integrity in patients with ppi\u2010responsive esophageal eosinophilia but not eosinophilic esophagitis.Clin Gastroenterol Hepatol2014; Mar 19. pii: S1542\u20103565(14)00392\u20109. doi:10.1016\/j.cgh.2014.02.037. 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