{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:07:35Z","timestamp":1762866455936,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"i\u00cc\u0081Shizu Matsumura donation at the Karolinska Insitutet","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Jane and Dan Olsson foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Majblomman foundation","award":["Project nr 61"],"award-info":[{"award-number":["Project nr 61"]}]},{"name":"Mj\u00c3\u00b6lkdroppen foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Samariten foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100007687","name":"Swedish Medical Society","doi-asserted-by":"crossref","award":["SLS-331681"],"award-info":[{"award-number":["SLS-331681"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergy and immune dysregulation may have a role in the pathophysiology of recurrent abdominal pain of functional origin, but previous studies of allergy\u2010related diseases and abdominal pain have contradictory results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the association between allergy\u2010related diseases or sensitisation during childhood and abdominal pain at age 12\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this birth cohort study of 4089 children, parents answered questionnaires regarding asthma, allergic rhinitis, eczema and food hypersensitivity (\u2018allergy\u2010related diseases\u2019) at ages 0,1,2,4,8 and 12\u00a0years. Blood for analyses of allergen\u2010specific IgE was sampled at 4 and 8\u00a0years. At 12\u00a0years, the children answered questions regarding abdominal pain. Children with coeliac disease or inflammatory bowel disease were excluded. Associations were examined using multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2610 children with complete follow\u2010up, 9% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0237) reported abdominal pain at 12\u00a0years. All allergy\u2010related diseases were associated with concurrent abdominal pain at 12\u00a0years and the risk increased with increasing number of allergy\u2010related diseases (<jats:italic>P<\/jats:italic> for trend &lt;0.001). Asthma at 1 and 2\u00a0years and food hypersensitivity at 8\u00a0years were significantly associated with abdominal pain at 12\u00a0years. There was an increased risk of abdominal pain at 12\u00a0years in children sensitised to food allergens at 4 or 8\u00a0years, but in stratified analyses, this was confined to children whose parents had <jats:italic>not<\/jats:italic> reported food hypersensitivity at time of sensitisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allergy\u2010related diseases as well as sensitisation to food allergens were associated with an elevated risk of abdominal pain, and the risk increased with the number of allergy\u2010related diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12965","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T09:02:03Z","timestamp":1412154123000},"page":"1349-1358","source":"Crossref","is-referenced-by-count":34,"title":["Allergy\u2010related diseases and recurrent abdominal pain during childhood \u2013 a birth cohort study"],"prefix":"10.1111","volume":"40","author":[{"given":"O.","family":"Ol\u00e9n","sequence":"first","affiliation":[{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital Stockholm Sweden"},{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5.","family":"Neuman","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"},{"name":"Department of Women\u2032s and Children\u2032s Health Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Koopmann","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Pediatrics \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ballardini","sequence":"additional","affiliation":[{"name":"Sachs' Children and Youth Hospital Stockholm South General Hospital Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Westman","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Division of Ear Nose and Throat Diseases Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mel\u00e9n","sequence":"additional","affiliation":[{"name":"Sachs' Children and 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