{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:34:52Z","timestamp":1792236892931,"version":"4.4.0"},"reference-count":173,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse reactions to food include immune mediated food allergies and non\u2010immune mediated food intolerances. Food allergies and intolerances are often confused by health professionals, patients and the public.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To critically review the data relating to diagnosis and management of food allergy and food intolerance in adults and children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and the Cochrane Database were searched up until May 2014, using search terms related to food allergy and intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An estimated one\u2010fifth of the population believe that they have adverse reactions to food. Estimates of true IgE\u2010mediated food allergy vary, but in some countries it may be as prevalent as 4\u20137% of preschool children. The most common food allergens are cow's milk, egg, peanut, tree nuts, soy, shellfish and finned fish. Reactions vary from urticaria to anaphylaxis and death. Tolerance for many foods including milk and egg develops with age, but is far less likely with peanut allergy. Estimates of IgE\u2010mediated food allergy in adults are closer to 1\u20132%. Non\u2010IgE\u2010mediated food allergies such as Food Protein\u2010Induced Enterocolitis Syndrome are rarer and predominantly recognised in childhood. Eosinophilic gastrointestinal disorders including eosinophilic oesophagitis are mixed IgE\u2010 and non\u2010IgE\u2010mediated food allergic conditions, and are improved by dietary exclusions. By contrast food intolerances are nonspecific, and the resultant symptoms resemble other common medically unexplained complaints, often overlapping with symptoms found in functional disorders such as irritable bowel syndrome. Improved dietary treatments for the irritable bowel syndrome have recently been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Food allergies are more common in children, can be life\u2010threatening and are distinct from food intolerances. Food intolerances may pose little risk but since functional disorders are so prevalent, greater efforts to understand adverse effects of foods in functional disorders are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12984","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T03:13:16Z","timestamp":1413342796000},"page":"3-25","source":"Crossref","is-referenced-by-count":241,"title":["Review article: the diagnosis and management of food allergy and food intolerances"],"prefix":"10.1111","volume":"41","author":[{"given":"J. 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