{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T20:14:19Z","timestamp":1724357659970},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Length of Barrett's oesophagus (<jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>) is a risk factor for oesophageal cancer. The underlying mechanisms that determine <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> length are nor fully known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine if there is a correlation between obesity and length of <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a population\u2010based study, 381 patients diagnosed with Barrett's oesophagus between 1999 and 2013 were included. Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) at the time of <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> diagnosis was calculated. Upper endoscopy reports were reviewed to obtain the length of <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>. Spearman's correlation coefficient was performed to assess the strength of the relationship between Barrett's length and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. A multivariate logistic regression analysis was conducted to further examine the association between <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and length of <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adjusted odds ratio for each five\u2010point increase in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was 1.5 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.24\u20131.81, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The mean <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was significantly higher in patients with long segment <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> as compared to patients with short segment <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> (32.7 vs. 30.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). There was also a positive trend in long segment <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> as patients entered into higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> categories (Z\u00a0=\u00a04.25, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was a significant correlation between <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and length of <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> (r\u00a0=\u00a00.25, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated a correlation between <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and the length of Barrett's oesophagus mucosa. Thus, increased <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> is associated with longer segment of Barrett's oesophagus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.12991","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T10:24:21Z","timestamp":1413541461000},"page":"137-144","source":"Crossref","is-referenced-by-count":17,"title":["The relationship between length of Barrett's oesophagus mucosa and body mass index"],"prefix":"10.1111","volume":"41","author":[{"given":"J.","family":"Abdallah","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Esophageal and Swallowing Center MetroHealth Medical Center Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Maradey\u2010Romero","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Esophageal and Swallowing Center MetroHealth Medical Center Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Center for Health Care Research and Policy Case Western Reserve University at MetroHealth Medical Center Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Perzynski","sequence":"additional","affiliation":[{"name":"Center for Health Care Research and Policy Case Western Reserve University at MetroHealth Medical Center Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fass","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology The Esophageal and Swallowing Center MetroHealth Medical Center Case Western Reserve University Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01835.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510033131404"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90847-X"},{"key":"e_1_2_7_5_1","first-page":"1494","article-title":"Barrett's esophagus in patients with symptomatic reflux esophagitis","volume":"84","author":"Mann NS","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_6_1","first-page":"AB82","article-title":"Prevalence of Barrett's esophagus and intestinal metaplasia at the esophagogastric junction [abstract]","volume":"112","author":"Cameron AJ","year":"1997","journal-title":"Gastroenterology"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605246"},{"key":"e_1_2_7_8_1","first-page":"669","article-title":"Trends in incidence of oesophageal and stomach cancer subtypes in Europe","volume":"22","author":"Steevens J","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70337-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.3.310"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05599.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0016-5107(03)00007-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.05.019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01602.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.046"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.08.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0636"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.026"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02674.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181612cac"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0411-y"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.174508"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00606-3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018834902694"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20262"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00031.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31829ae98c"}],"container-title":["Alimentary Pharmacology &amp; 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